CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018552
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein kinase 17B 
Protein Synonyms/Alias
 DAP kinase-related apoptosis-inducing protein kinase 2 
Gene Name
 Stk17b 
Gene Synonyms/Alias
 Drak2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
37NFYTLTPKELGRGKFacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains. 
Sequence Annotation
 DOMAIN 33 293 Protein kinase.
 NP_BIND 39 47 ATP (By similarity).
 ACT_SITE 158 158 Proton acceptor (By similarity).
 BINDING 62 62 ATP (By similarity).  
Keyword
 Apoptosis; ATP-binding; Cell membrane; Complete proteome; Kinase; Membrane; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 371 AA 
Protein Sequence
MSRRRFDCRS ISGLLTTTPQ TPMKTENFNN FYTLTPKELG RGKFAVVRQC ISKSTGQEYA 60
AKFLKKRRRG QDCRAEILHE IAVLELARSC PHVINLHEVY ETATEIILVL EYAAGGEIFN 120
LCLPELAEMV SENDVIRLIK QILEGVHYLH QNNIVHLDLK PQNILLSSIY PLGDIKIVDF 180
GMSRKIGNAS ELREIMGTPE YLAPEILNYD PITTATDMWN IGIIAYMLLT HTSPFVGEDN 240
QETYLNISQV NVDYSEEMFS SVSQLATDFI QSLLVKNPEK RPTAESCLSH SWLQQWDFGS 300
LFHPEETSES SQTQDLSLRS SEDKTPKSCN GSCGDREDKE NIPEDDSLLS KRFRFDDSLP 360
SPHELVPDLF C 371 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IMP:UniProtKB.
 GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IDA:UniProtKB.
 GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0006917; P:induction of apoptosis; IMP:UniProtKB.
 GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.
 GO:0012501; P:programmed cell death; IDA:RGD.
 GO:0046777; P:protein autophosphorylation; IDA:UniProtKB. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS