| Tag | Content |
|---|
| CPLM ID | CPLM-006486 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Histidine ammonia-lyase |
Protein Synonyms/Alias | Histidase |
Gene Name | Hal |
Gene Synonyms/Alias | Hsd; Huth |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 172 | GITTGFGKFARTVIP | ubiquitination | [1] | | 182 | RTVIPANKLQELQVN | ubiquitination | [1] | | 200 | SHSSGVGKPLSPERC | ubiquitination | [1] | | 220 | LRINVLAKGYSGISL | ubiquitination | [1] | | 277 | EGKMWSPKSGWADAK | ubiquitination | [1] | | 293 | VLEAHGLKPIVLKPK | ubiquitination | [1] | | 298 | GLKPIVLKPKEGLAL | ubiquitination | [1] | | 300 | KPIVLKPKEGLALIN | ubiquitination | [1] | | 342 | ALTLEVLKGTTKAFD | ubiquitination | [1] | | 346 | EVLKGTTKAFDTDIH | ubiquitination | [1] | | 578 | KTTTPLEKVYDLVRS | ubiquitination | [1] | | 592 | SVVRPWIKDRFMAPD | ubiquitination | [1] | | 611 | HRLLLDQKVWEVAAP | ubiquitination | [1] | | 622 | VAAPYIEKYRMEHIP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | |
Sequence Annotation | MOD_RES 254 254 2,3-didehydroalanine (Ser) (By
MOD_RES 631 631 Phosphoserine.
MOD_RES 635 635 Phosphoserine.
MOD_RES 648 648 Phosphoserine.
CROSSLNK 253 255 5-imidazolinone (Ala-Gly) (By |
Keyword | Complete proteome; Disease mutation; Histidine metabolism; Lyase; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 657 AA |
Protein Sequence | MPRYTVHVRG EWLAVPCQDG KLTVGWLGRE AVRRYMKNKP DNGGFTSVDE VQFLVHRCKG 60
LGLLDNEDEL EVALEDNEFV EVVIEGDVMS PDFIPSQPEG VFLYSKYREP EKYIALDGDS 120
LSTEDLVNLG KGRYKIKLTS IAEKKVQQSR EVIDSIIKER TVVYGITTGF GKFARTVIPA 180
NKLQELQVNL VRSHSSGVGK PLSPERCRML LALRINVLAK GYSGISLETL KQVIEAFNAS 240
CLSYVPEKGT VGASGDLAPL SHLALGLIGE GKMWSPKSGW ADAKYVLEAH GLKPIVLKPK 300
EGLALINGTQ MITSLGCEAL ERASAIARQA DIVAALTLEV LKGTTKAFDT DIHAVRPHRG 360
QIEVAFRFRS LLDSDHHPSE IAESHRFCDR VQDAYTLRCC PQVHGVVNDT IAFVKDIITT 420
ELNSATDNPM VFASRGETIS GGNFHGEYPA KALDYLAIGV HELAAISERR IERLCNPSLS 480
ELPAFLVAEG GLNSGFMIAH CTAAALVSES KALCHPSSVD SLSTSAATED HVSMGGWAAR 540
KALRVVEHVE QVLAIELLAA CQGIEFLRPL KTTTPLEKVY DLVRSVVRPW IKDRFMAPDI 600
EAAHRLLLDQ KVWEVAAPYI EKYRMEHIPE SRPLSPTAFS LESLRKNSAT IPESDDL 657 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:InterPro. GO:0004397; F:histidine ammonia-lyase activity; IDA:MGI. GO:0009058; P:biosynthetic process; IEA:InterPro. GO:0006548; P:histidine catabolic process; IDA:MGI. GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway. GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |