CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021598
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pleckstrin homology domain-containing family A member 1 
Protein Synonyms/Alias
 PH domain-containing family A member 1; Tandem PH domain-containing protein 1; TAPP-1 
Gene Name
 PLEKHA1 
Gene Synonyms/Alias
 TAPP1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
72SKVSDATKLRPKAEFubiquitination[1]
117AIKITVPKQSDSQPNubiquitination[1]
229YFKSELEKEPLRVIPubiquitination[1, 2]
238PLRVIPLKEVHKVQEubiquitination[1]
247VHKVQECKQSDIMMRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. 
Sequence Annotation
 DOMAIN 7 112 PH 1.
 DOMAIN 191 289 PH 2.
 MOD_RES 362 362 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Lipid-binding; Membrane; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 404 AA 
Protein Sequence
MPYVDRQNRI CGFLDIEENE NSGKFLRRYF ILDTREDSFV WYMDNPQNLP SGSSRVGAIK 60
LTYISKVSDA TKLRPKAEFC FVMNAGMRKY FLQANDQQDL VEWVNVLNKA IKITVPKQSD 120
SQPNSDNLSR HGECGKKQVS YRTDIVGGVP IITPTQKEEV NECGESIDRN NLKRSQSHLP 180
YFTPKPPQDS AVIKAGYCVK QGAVMKNWKR RYFQLDENTI GYFKSELEKE PLRVIPLKEV 240
HKVQECKQSD IMMRDNLFEI VTTSRTFYVQ ADSPEEMHSW IKAVSGAIVA QRGPGRSASS 300
EHPPGPSESK HAFRPTNAAT ATSHSTASRS NSLVSTFTME KRGFYESLAK VKPGNFKVQT 360
VSPREPASKV TEQALLRPQS KNGPQEKDCD LVDLDDASLP VSDV 404 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0032587; C:ruffle membrane; IDA:UniProtKB.
 GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IDA:UniProtKB.
 GO:0008209; P:androgen metabolic process; IEA:Compara.
 GO:0050853; P:B cell receptor signaling pathway; IDA:UniProtKB.
 GO:0070301; P:cellular response to hydrogen peroxide; IDA:UniProtKB.
 GO:0045184; P:establishment of protein localization; IDA:UniProtKB.
 GO:0008210; P:estrogen metabolic process; IEA:Compara.
 GO:0060325; P:face morphogenesis; IEA:Compara.
 GO:0033327; P:Leydig cell differentiation; IEA:Compara.
 GO:0001553; P:luteinization; IEA:Compara.
 GO:0035264; P:multicellular organism growth; IEA:Compara.
 GO:0051898; P:negative regulation of protein kinase B signaling cascade; IMP:UniProtKB.
 GO:0060021; P:palate development; IEA:Compara.
 GO:0014065; P:phosphatidylinositol 3-kinase cascade; IDA:UniProtKB.
 GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0031529; P:ruffle organization; IDA:UniProtKB.
 GO:0048705; P:skeletal system morphogenesis; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:Compara. 
Interpro
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF00169; PH 
SMART
 SM00233; PH 
PROSITE
 PS50003; PH_DOMAIN 
PRINTS