| Tag | Content |
|---|
| CPLM ID | CPLM-014760 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Integrator complex subunit 12 |
Protein Synonyms/Alias | Int12; PHD finger protein 22 |
Gene Name | Ints12 |
Gene Synonyms/Alias | Phf22 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 68 | STKSLSIKQEPKTSS | acetylation | [1] | | 91 | GKVLAAEKLKKEAEK | acetylation | [1] | | 262 | ETTFLAFKRTEVKPS | acetylation | [1] | | 319 | TAQNSSGKPAASSAS | acetylation | [1] | | 360 | TSPSVPLKPLPPLTL | acetylation | [1] | | 445 | ESQLNAMKRLQMVKK | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (By similarity). |
Sequence Annotation | ZN_FING 158 214 PHD-type.
MOD_RES 127 127 Phosphoserine (By similarity). |
Keyword | Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 461 AA |
Protein Sequence | MAATVNLELD PIFLKALGFL HSKSKDSAEK LKTLLDESLA RGIDASYRPA QKDVEPPKIS 60
STKSLSIKQE PKTSSSLPSG SSNGKVLAAE KLKKEAEKRP ADKMKDATEG VDVPKKPRLE 120
KPETRSSPIT VQTSKDLAMA DLSSFEETSA DDFAMEMGLA CVVCRQMTVA SGNQLVECQE 180
CHNLYHQDCH KPQVTDKEVN DPRLVWYCAR CTRQMKRMAQ KTQKPPQKPA PTVVSVAPTV 240
KDPLVKKPET KLKQETTFLA FKRTEVKPST VISGNSSSNN VSSSVTSGLT GWAAFAAKTS 300
SAGPSTAKLN STAQNSSGKP AASSASQKPV GLTGLATSSK GGIGSKIGSS NSTSPSVPLK 360
PLPPLTLGKT GLSRSVSCDN VSKVGLPSPS SLVPGGSSQL SGNGNSATAG PTGSITSKTT 420
SETSSSTSAS LKGPTSQESQ LNAMKRLQMV KKKAAQKKLK K 461 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |