UniProt Accession

 GNAL_HUMAN; P38405; B7ZA26; Q86XU3 

Genbank Protein ID

 L10665; U55184; U55180; U55181; U55182; U55183; AF493893; AK316141; AP001120; AP001269; AP005137; CH471113; BC050021 

Genbank Nucleotide ID

 AAC37535.1; AAD00085.1; AAD00085.1; AAD00085.1; AAD00085.1; AAD00085.1; AAM12607.1; BAH14512.1; EAX01573.1; AAH50021.1 

Protein Name

 Guanine nucleotide-binding protein G(olf) subunit alpha 

Protein Synonyms/Alias

 Adenylate cyclase-stimulating G alpha protein, olfactory type 

Gene Name

 GNAL 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
55	LGAGESGKSTIVKQM	ubiquitination	[1]
60	SGKSTIVKQMRILHV	ubiquitination	[1]
203	ETRFQVDKVNFHMFD	ubiquitination	[1]
292	AEKVLAGKSKIEDYF	ubiquitination	[1, 2]
294	KVLAGKSKIEDYFPE	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters. 

Sequence Annotation

 NP_BIND 49 56 GTP (By similarity).
 NP_BIND 185 191 GTP (By similarity).
 NP_BIND 210 214 GTP (By similarity).
 NP_BIND 279 282 GTP (By similarity).
 METAL 56 56 Magnesium (By similarity).
 METAL 191 191 Magnesium (By similarity).
 BINDING 353 353 GTP; via amide nitrogen (By similarity).
 MOD_RES 188 188 ADP-ribosylarginine; by cholera toxin (By
 LIPID 2 2 N-palmitoyl glycine (By similarity).
 LIPID 3 3 S-palmitoyl cysteine (By similarity).  

Keyword

 ADP-ribosylation; Alternative splicing; Complete proteome; Disease mutation; Dystonia; GTP-binding; Lipoprotein; Magnesium; Metal-binding; Nucleotide-binding; Palmitate; Polymorphism; Reference proteome; Transducer. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 381 AA 

Protein Sequence

Gene Ontology

 GO:0005834; C:heterotrimeric G-protein complex; IBA:RefGenome.
 GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome.
 GO:0001664; F:G-protein coupled receptor binding; IBA:RefGenome.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; TAS:ProtInc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004871; F:signal transducer activity; IBA:RefGenome.
 GO:0007190; P:activation of adenylate cyclase activity; IEA:Compara.
 GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; IBA:RefGenome.
 GO:0007193; P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; TAS:Reactome.
 GO:0001975; P:response to amphetamine; IEA:Compara.
 GO:0031000; P:response to caffeine; IEA:Compara.
 GO:0007608; P:sensory perception of smell; IBA:RefGenome.
 GO:0007268; P:synaptic transmission; TAS:Reactome. 

Interpro

 IPR000367; Gprotein_alpha_S.
 IPR001019; Gprotein_alpha_su.
 IPR011025; GproteinA_insert.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00503; G-alpha 

SMART

 SM00275; G_alpha 

PROSITE

  

PRINTS

 PR00318; GPROTEINA.
 PR00443; GPROTEINAS.