UniProt Accession

 COMD1_HUMAN; Q8N668; Q96GS0 

Genbank Protein ID

 AB178811; BC009266; BC022046 

Genbank Nucleotide ID

 BAD18972.1; AAH09266.2; AAH22046.1 

Protein Name

 COMM domain-containing protein 1 

Protein Synonyms/Alias

 Protein Murr1 

Gene Name

 COMMD1 

Gene Synonyms/Alias

 C2orf5; MURR1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
81	AFLTAQTKKQGGITS	ubiquitination	[1]
82	FLTAQTKKQGGITSD	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes. 

Sequence Annotation

 DOMAIN 118 186 COMM.
 METAL 101 101 Copper (Potential).
 METAL 110 110 Copper (Potential).
 METAL 134 134 Copper (Potential).
 MOD_RES 2 2 N-acetylalanine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Copper; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Ubl conjugation; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 190 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IDA:HPA.
 GO:0031462; C:Cul2-RING ubiquitin ligase complex; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005507; F:copper ion binding; IDA:UniProtKB.
 GO:0055070; P:copper ion homeostasis; IDA:UniProtKB.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.
 GO:0031398; P:positive regulation of protein ubiquitination; IDA:UniProtKB.
 GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB. 

Interpro

 IPR017920; COMM.
 IPR009886; HCaRG. 

Pfam

 PF07258; HCaRG 

SMART

  

PROSITE

 PS51269; COMM 

PRINTS