| Tag | Content |
|---|
| CPLM ID | CPLM-024126 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Integrin-linked kinase-associated serine/threonine phosphatase 2C |
Protein Synonyms/Alias | ILKAP; PP2Cdelta |
Gene Name | Ilkap |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 356 | KIQTREGKPAVDARY | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation (By similarity). |
Sequence Annotation | DOMAIN 128 390 PP2C-like.
METAL 152 152 Manganese 1 (By similarity).
METAL 152 152 Manganese 2 (By similarity).
METAL 153 153 Manganese 1; via carbonyl oxygen (By
METAL 326 326 Manganese 2 (By similarity).
METAL 381 381 Manganese 2 (By similarity).
MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 210 210 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Complete proteome; Cytoplasm; Hydrolase; Magnesium; Manganese; Metal-binding; Protein phosphatase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 392 AA |
Protein Sequence | MDLFGDLPEP ERPPRPSAGK EAQEGPVLFE DLPPTSSTDS GSGGPLLFDG LPPAGSGNSG 60
SLATSGSQVV KNEGKGAKRK APEEEKNGGE ELVEKKVCKA SSVIFGLKGY VAERKGEREE 120
MQDAHVILND ITQECNPPSS LITRVSYFAV FDGHGGIRAS KFAAQNLHQN LIRKFPKGDV 180
ISVEKTVKRC LLDTFKHTDE EFLKQASSQK PAWKDGSTAT CVLAVDNILY IANLGDSRAI 240
LCRYNEESQK HAALSLSKEH NPTQYEERMR IQKAGGNVRD GRVLGVLEVS RSIGDGQYKR 300
CGVTSVPDIR RCQLTPNDRF ILLACDGLFK VFTPEEAVNF ILSCLEDEKI QTREGKPAVD 360
ARYEAACNRL ANKAVQRGSA DNVTVMVVRI GH 392 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004722; F:protein serine/threonine phosphatase activity; IDA:RGD. GO:0006470; P:protein dephosphorylation; IDA:RGD. GO:0033262; P:regulation of nuclear cell cycle DNA replication; IDA:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |