UniProt Accession

 AROD_ECOLI; P05194 

Genbank Protein ID

 X59503; X04306; U00096; AP009048 

Genbank Nucleotide ID

 CAA42091.1; CAA27849.1; AAC74763.1; BAA15448.1 

Protein Name

 3-dehydroquinate dehydratase 

Protein Synonyms/Alias

 3-dehydroquinase; Type I DHQase 

Gene Name

 aroD 

Gene Synonyms/Alias

 b1693; JW1683 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
31	AKDIASVKSEALAYR	acetylation	[1]
66	ESVMAAAKILRETMP	acetylation	[1]
137	YAHAHDVKVVMSNHD	acetylation	[1]
147	MSNHDFHKTPEAEEI	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

  

Sequence Annotation

 REGION 46 48 Substrate binding (By similarity).
 ACT_SITE 143 143 Proton donor/acceptor.
 ACT_SITE 170 170 Schiff-base intermediate with substrate.
 BINDING 82 82 Substrate (By similarity).
 BINDING 213 213 Substrate (By similarity).
 BINDING 232 232 Substrate (By similarity).
 BINDING 236 236 Substrate (By similarity).  

Keyword

 Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; Direct protein sequencing; Lyase; Reference proteome; Schiff base. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 252 AA 

Protein Sequence

Gene Ontology

 GO:0003855; F:3-dehydroquinate dehydratase activity; IEA:HAMAP.
 GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:HAMAP.
 GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR018508; 3-dehydroquinate_DH_AS.
 IPR013785; Aldolase_TIM.
 IPR001381; DHquinase_I. 

Pfam

 PF01487; DHquinase_I 

SMART

  

PROSITE

 PS01028; DEHYDROQUINASE_I 

PRINTS