UniProt Accession

 COA1_HUMAN; Q9GZY4; A6NJU8; A8KAH8; Q9HAB7; Q9NVD2 

Genbank Protein ID

 AK001665; AK021905; AK023007; AK023053; AK293043; AC005189; CH471073; BC056884 

Genbank Nucleotide ID

 BAA91821.1; BAB13932.1; BAB14356.1; BAB14379.1; BAF85732.1; EAW94165.1; AAH56884.1 

Protein Name

 Cytochrome c oxidase assembly protein 1 homolog 

Protein Synonyms/Alias

 Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 15 kDa 

Gene Name

 COA1 

Gene Synonyms/Alias

 C7orf44; MITRAC15 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
5	***MMWQKYAGSRRS	ubiquitination	[1]
74	PLNIHYLKLIDRENF	ubiquitination	[2, 3]
88	FVDIVDAKLKIPVSG	ubiquitination	[1, 2, 3]
90	DIVDAKLKIPVSGSK	ubiquitination	[1, 2]
97	KIPVSGSKSEGLLYV	ubiquitination	[1, 2]
125	DEVFLELKDGQQIPV	ubiquitination	[2, 4]
134	GQQIPVFKLSGENGD	ubiquitination	[2]
144	GENGDEVKKE*****	ubiquitination	[1, 2]
145	ENGDEVKKE******	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex that regulates COX assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV. 

Sequence Annotation

  

Keyword

 Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 146 AA 

Protein Sequence

Gene Ontology

 GO:0031305; C:integral to mitochondrial inner membrane; IDA:UniProtKB.
 GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:UniProtKB.
 GO:0033617; P:mitochondrial respiratory chain complex IV assembly; IMP:UniProtKB. 

Interpro

 IPR014807; Cyt_oxidase_assembly-1. 

Pfam

 PF08695; Coa1 

SMART

  

PROSITE

  

PRINTS