| Tag | Content |
|---|
| CPLM ID | CPLM-010805 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial |
Protein Synonyms/Alias | Branched-chain alpha-ketoacid dehydrogenase kinase; BCKD-kinase; BCKDHKIN |
Gene Name | Bckdk |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 163 | RQLLDDHKDVVTLLA | acetylation | [1] | | 184 | RKHIEDEKLVRYFLD | acetylation | [1] | | 192 | LVRYFLDKTLTSRLG | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex. |
Sequence Annotation | DOMAIN 159 404 Histidine kinase.
MOD_RES 31 31 Phosphoserine (By similarity).
MOD_RES 35 35 Phosphothreonine (By similarity).
MOD_RES 192 192 N6-acetyllysine (By similarity).
MOD_RES 233 233 N6-acetyllysine (By similarity). |
Keyword | 3D-structure; Acetylation; ATP-binding; Complete proteome; Direct protein sequencing; Kinase; Mitochondrion; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 412 AA |
Protein Sequence | MILTSVLGSG PRSGSSLWPL LGSSLSLRVR STSATDTHHV ELARERSKTV TSFYNQSAID 60
VVAEKPSVRL TPTMMLYSGR SQDGSHLLKS GRYLQQELPV RIAHRIKGFR SLPFIIGCNP 120
TILHVHELYI RAFQKLTDFP PIKDQADEAQ YCQLVRQLLD DHKDVVTLLA EGLRESRKHI 180
EDEKLVRYFL DKTLTSRLGI RMLATHHLAL HEDKPDFVGI ICTRLSPKKI IEKWVDFARR 240
LCEHKYGNAP RVRINGHVAA RFPFIPMPLD YILPELLKNA MRATMESHLD TPYNVPDVVI 300
TIANNDVDLI IRISDRGGGI AHKDLDRVMD YHFTTAEAST QDPRISPLFG HLDMHSGGQS 360
GPMHGFGFGL PTSRAYAEYL GGSLQLQSLQ GIGTDVYLRL RHIDGREESF RI 412 |
Gene Ontology | GO:0005947; C:mitochondrial alpha-ketoglutarate dehydrogenase complex; IDA:HGNC. GO:0047323; F:[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity; IMP:RGD. GO:0005524; F:ATP binding; IDA:HGNC. GO:0004674; F:protein serine/threonine kinase activity; IDA:HGNC. GO:0009083; P:branched-chain amino acid catabolic process; IDA:HGNC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |