UniProt Accession

 E0CZE0_MOUSE; E0CZE0 

Genbank Protein ID

 AC130543 

Genbank Nucleotide ID

  

Protein Name

 NEDD8-activating enzyme E1 regulatory subunit 

Protein Synonyms/Alias

  

Gene Name

 Nae1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
6	**MAQPGKILKEQKY	acetylation	[1]
9	AQPGKILKEQKYDRQ	ubiquitination	[2]
163	LEDLRLDKPFPELRE	ubiquitination	[2]
182	YDLDHMEKKDHSHTP	ubiquitination	[2]
216	IPKSYKEKEDFRDLI	ubiquitination	[2]
229	LIRQGILKNENGAPE	ubiquitination	[2]
288	WILARALKEFVAKEG	ubiquitination	[2]
293	ALKEFVAKEGQGNLP	ubiquitination	[2]
314	DMIADSNKYIKLQNV	ubiquitination	[2]
317	ADSNKYIKLQNVYRE	acetylation	[1]
317	ADSNKYIKLQNVYRE	ubiquitination	[2]
339	AVGNHVAKLLQSVGQ	ubiquitination	[2]
354	APESISEKELKLLCS	acetylation	[1, 3]
354	APESISEKELKLLCS	ubiquitination	[2]
432	QVEEDIGKLKSCLTG	acetylation	[3]
432	QVEEDIGKLKSCLTG	ubiquitination	[2]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 510 AA 

Protein Sequence

Gene Ontology

  

Interpro

 IPR009036; Molybdenum_cofac_synth_MoeB.
 IPR016040; NAD(P)-bd_dom. 

Pfam

  

SMART

  

PROSITE

  

PRINTS