CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001484
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transmembrane protein 63A 
Protein Synonyms/Alias
  
Gene Name
 TMEM63A 
Gene Synonyms/Alias
 KIAA0489; KIAA0792 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
221HTQSIKYKEENLVRRubiquitination[1]
241GLPRDARKETVESHFubiquitination[1]
274AKLIYLCKEKKKTEKubiquitination[1]
365SMATYILKDFNACKCubiquitination[1]
371LKDFNACKCQSLQCKubiquitination[1, 2]
378KCQSLQCKGEPQPSSubiquitination[1, 2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
 CARBOHYD 38 38 N-linked (GlcNAc...) (Potential).
 CARBOHYD 450 450 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Lysosome; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 807 AA 
Protein Sequence
MMDSPFLELW QSKAVSIREQ LGLGDRPNDS YCYNSAKNST VLQGVTFGGI PTVLLIDVSC 60
FLFLILVFSI IRRRFWDYGR IALVSEADSE SRFQRLSSTS SSGQQDFENE LGCCPWLTAI 120
FRLHDDQILE WCGEDAIHYL SFQRHIIFLL VVVSFLSLCV ILPVNLSGDL LDKDPYSFGR 180
TTIANLQTDN DLLWLHTIFA VIYLFLTVGF MRHHTQSIKY KEENLVRRTL FITGLPRDAR 240
KETVESHFRD AYPTCEVVDV QLCYNVAKLI YLCKEKKKTE KSLTYYTNLQ VKTGQRTLIN 300
PKPCGQFCCC EVLGCEWEDA ISYYTRMKDR LLERITEEER HVQDQPLGMA FVTFQEKSMA 360
TYILKDFNAC KCQSLQCKGE PQPSSHSREL YTSKWTVTFA ADPEDICWKN LSIQGLRWWL 420
QWLGINFTLF LGLFFLTTPS IILSTMDKFN VTKPIHALNN PIISQFFPTL LLWSFSALLP 480
SIVYYSTLLE SHWTKSGENQ IMMTKVYIFL IFMVLILPSL GLTSLDFFFR WLFDKTSSEA 540
SIRLECVFLP DQGAFFVNYV IASAFIGNGM ELLRLPGLIL YTFRMIMAKT AADRRNVKQN 600
QAFQYEFGAM YAWMLCVFTV IVAYSITCPI IAPFGLIYIL LKHMVDRHNL YFVYLPAKLE 660
KGIHFAAVNQ ALAAPILCLF WLYFFSFLRL GMKAPATLFT FLVLLLTILV CLAHTCFGCF 720
KHLSPLNYKT EEPASDKGSE AEAHMPPPFT PYVPRILNGL ASERTALSPQ QQQQQTYGAI 780
HNISGTIPGQ CLAQSATGSV AAAPQEA 807 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro. 
Interpro
 IPR003864; DUF221.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR026957; TMEM63. 
Pfam
 PF02714; DUF221 
SMART
  
PROSITE
  
PRINTS