UniProt Accession

 ZFAN6_MOUSE; Q9DCH6; Q9ER79 

Genbank Protein ID

 AJ251508; AK002775; AK144902; BC010683 

Genbank Nucleotide ID

 CAC14886.1; BAB22349.1; BAE26124.1; AAH10683.1 

Protein Name

 AN1-type zinc finger protein 6 

Protein Synonyms/Alias

 Associated with PRK1 protein; Zinc finger A20 domain-containing protein 3 

Gene Name

 Zfand6 

Gene Synonyms/Alias

 Awp1; Za20d3 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
219	NPVVVGEKIQKI***	acetylation	[1, 2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'- linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1 (By similarity). Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes. 

Sequence Annotation

 ZN_FING 8 42 A20-type.
 ZN_FING 161 204 AN1-type.  

Keyword

 Apoptosis; Complete proteome; Cytoplasm; Metal-binding; Protein transport; Reference proteome; Transport; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 223 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0031593; F:polyubiquitin binding; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0071356; P:cellular response to tumor necrosis factor; ISS:UniProtKB.
 GO:0006625; P:protein targeting to peroxisome; IDA:UniProtKB.
 GO:0042981; P:regulation of apoptotic process; ISS:UniProtKB.
 GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB. 

Interpro

 IPR002653; Znf_A20.
 IPR000058; Znf_AN1. 

Pfam

 PF01754; zf-A20
 PF01428; zf-AN1 

SMART

 SM00259; ZnF_A20
 SM00154; ZnF_AN1 

PROSITE

 PS51036; ZF_A20
 PS51039; ZF_AN1 

PRINTS