UniProt Accession

 DPIA_ECOLI; P0AEF4; Q54149 

Genbank Protein ID

 U46667; U82598; U00096; AP009048 

Genbank Nucleotide ID

 AAC28952.1; AAB40820.1; AAC73721.1; BAA35256.1 

Protein Name

 Transcriptional regulatory protein DpiA 

Protein Synonyms/Alias

 Destabilizer of plasmid inheritance 

Gene Name

 dpiA 

Gene Synonyms/Alias

 citB; criR; mpdA; b0620; JW0612 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
137	SIDSASQKQIDEMFN	acetylation	[1]
172	NAVRKLFKEPGVQHT	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Member of the two-component regulatory system DpiA/DpiB, which is essential for expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. Could be involved in response to both the presence of citrate and external redox conditions. Regulates the transcription of citCDEFXGT, dpiAB, mdh and exuT. Binds specifically to the dpiB-citC intergenic region. 

Sequence Annotation

 DOMAIN 6 122 Response regulatory.
 DNA_BIND 180 199 H-T-H motif (By similarity).
 MOD_RES 57 57 4-aspartylphosphate (By similarity).  

Keyword

 Activator; Complete proteome; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Two-component regulatory system. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 226 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IDA:EcoCyc.
 GO:0001071; F:nucleic acid binding transcription factor activity; IEA:InterPro.
 GO:0000156; F:phosphorelay response regulator activity; IDA:EcoCyc.
 GO:0006355; P:regulation of transcription, DNA-dependent; IMP:EcoCyc.
 GO:0009605; P:response to external stimulus; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR011006; CheY-like_superfamily.
 IPR024187; Sig_transdc_resp-reg_cit/mal.
 IPR001789; Sig_transdc_resp-reg_receiver. 

Pfam

 PF00072; Response_reg 

SMART

 SM00448; REC 

PROSITE

 PS50110; RESPONSE_REGULATORY 

PRINTS