UniProt Accession

 T2AG_HUMAN; P52657; A8MYQ7; Q6FGB5 

Genbank Protein ID

 X81713; U14193; U21242; BT007362; CR542192; AC092755; CH471082; BC000287; BC001919 

Genbank Nucleotide ID

 CAA57357.1; AAA64951.1; AAB58247.1; AAP36026.1; CAG46989.1; EAW77573.1; AAH00287.1; AAH01919.1 

Protein Name

 Transcription initiation factor IIA subunit 2 

Protein Synonyms/Alias

 General transcription factor IIA subunit 2; TFIIA p12 subunit; TFIIA-12; TFIIAS; Transcription initiation factor IIA gamma chain; TFIIA-gamma 

Gene Name

 GTF2A2 

Gene Synonyms/Alias

 TF2A2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
89	REVTELIKVDKVKIV	ubiquitination	[1]
94	LIKVDKVKIVACDGK	ubiquitination	[1]
101	KIVACDGKNTGSNTT	ubiquitination	[1, 2, 3, 4, 5]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Host-virus interaction; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 109 AA 

Protein Sequence

Gene Ontology

 GO:0005672; C:transcription factor TFIIA complex; IDA:BHF-UCL.
 GO:0003713; F:transcription coactivator activity; IDA:BHF-UCL.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0051123; P:RNA polymerase II transcriptional preinitiation complex assembly; IDA:BHF-UCL.
 GO:0006368; P:transcription elongation from RNA polymerase II promoter; TAS:Reactome.
 GO:0022415; P:viral reproductive process; TAS:Reactome.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR009083; TFIIA_a-hlx.
 IPR009088; TFIIA_b-brl.
 IPR003194; TFIIA_gsu.
 IPR015871; TFIIA_gsu_C.
 IPR015872; TFIIA_gsu_N. 

Pfam

 PF02751; TFIIA_gamma_C
 PF02268; TFIIA_gamma_N 

SMART

  

PROSITE

  

PRINTS