UniProt Accession

 SDHL_MOUSE; Q8VBT2 

Genbank Protein ID

 BC021605; BC021950 

Genbank Nucleotide ID

 AAH21605.1; AAH21950.1 

Protein Name

 L-serine dehydratase/L-threonine deaminase 

Protein Synonyms/Alias

 SDH; L-serine deaminase; L-threonine dehydratase; TDH 

Gene Name

 Sds 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
100	ALTIERLKNEGATVE	ubiquitination	[1]
215	GKLVTLPKITSVAKA	ubiquitination	[1]
221	PKITSVAKALGVNTV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 41 41 N6-(pyridoxal phosphate)lysine (By  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Gluconeogenesis; Lyase; Pyridoxal phosphate; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 327 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0003941; F:L-serine ammonia-lyase activity; IEA:EC.
 GO:0004794; F:L-threonine ammonia-lyase activity; IEA:EC.
 GO:0030170; F:pyridoxal phosphate binding; IEA:Compara.
 GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
 GO:0006565; P:L-serine catabolic process; IEA:Compara.
 GO:0042866; P:pyruvate biosynthetic process; IEA:Compara.
 GO:0043200; P:response to amino acid stimulus; IEA:Compara.
 GO:0033590; P:response to cobalamin; IEA:Compara. 

Interpro

 IPR000634; Ser/Thr_deHydtase_PyrdxlP-BS.
 IPR001926; Trp_syn_b_sub_like_PLP_eny_SF. 

Pfam

 PF00291; PALP 

SMART

  

PROSITE

 PS00165; DEHYDRATASE_SER_THR 

PRINTS