CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037368
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 WD repeat-containing protein 6 
Protein Synonyms/Alias
  
Gene Name
 WDR6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
39MVAVFGSKGLRVVKIubiquitination[1]
186DRSVRIWKVGDLRVPubiquitination[1, 2, 3, 4, 5, 6]
292GVSALCFKSRSRPGTubiquitination[3, 4, 5, 6]
301RSRPGTLKAVTLAGSubiquitination[3, 5]
367ANGEGRVKVVPINTPubiquitination[1, 3, 4, 5, 6, 7]
386DQTLFPGKVHSLSWAubiquitination[2, 3, 5, 6]
439RYLLPPSKQRWHTCSubiquitination[1, 2, 4, 5, 6]
475PSRPGLLKDPGVGGKubiquitination[1, 2, 3, 4, 5, 6, 7]
482KDPGVGGKARAGAGAubiquitination[1]
804RNRHRMVKVDPETRYubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [7] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1070 AA 
Protein Sequence
MIKRVQNLLG HYLIHGFRVR PEPNGDLDLE AMVAVFGSKG LRVVKISWGQ GHFWELWRSG 60
LWNMSDWIWD ARWLEGNIAL ALGHNSVVLY DPVVGCILQE VPCTDRCTLS SACLIGDAWK 120
ELTIVAGAVS NQLLVWYPAT ALADNKPVAP DRRISGHVGI IFSMSYLESK GLLATASEDR 180
SVRIWKVGDL RVPGGRVQNI GHCFGHSARV WQVKLLENYL ISAGEDCVCL VWSHEGEILQ 240
AFRGHQGRGI RAIAAHERQA WVITGGDDSG IRLWHLVGRG YRGLGVSALC FKSRSRPGTL 300
KAVTLAGSWR LLAVTDTGAL YLYDVEVKCW EQLLEDKHFQ SYCLLEAAPG PEGFGLCAMA 360
NGEGRVKVVP INTPTAAVDQ TLFPGKVHSL SWALRGYEEL LLLASGPGGV VACLEISAAP 420
SGKAIFVKER CRYLLPPSKQ RWHTCSAFLP PGDFLVCGDR RGSVLLFPSR PGLLKDPGVG 480
GKARAGAGAP VVGSGSSGGG NAFTGLGPVS TLPSLHGKQG VTSVTCHGGY VYTTGRDGAY 540
YQLFVRDGQL QPVLRQKSCR GMNWLAGLRI VPDGSMVILG FHANEFVVWN PRSHEKLHIV 600
NCGGGHRSWA FSDTEAAMAF AYLKDGDVML YRALGGCTRP HVILREGLHG REITCVKRVG 660
TITLGPEYGV PSFMQPDDLE PGSEGPDLTD IVITCSEDTT VCVLALPTTT GSAHALTAVC 720
NHISSVRAVA VWGIGTPGGP QDPQPGLTAH VVSAGGRAEM HCFSIMVTPD PSTPSRLACH 780
VMHLSSHRLD EYWDRQRNRH RMVKVDPETR YMSLAVCELD QPGLGPLVAA ACSDGAVRLF 840
LLQDSGRILQ LLAETFHHKR CVLKVHSFTH EAPNQRRRLL LCSAATDGSL AFWDLTTMLD 900
HDSTVLEPPV DPGLPYRLGT PSLTLQAHSC GINSLHTLPT REGHHLVASG SEDGSLHVFV 960
LAVEMLQLEE AVGEAGLVPQ LRVLEEYSVP CAHAAHVTGL KILSPSIMVS ASIDQRLTFW 1020
RLGHGEPTFM NSTVFHVPDV ADMDCWPVSP EFGHRCALGG QGLEVYNWYD 1070 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0043234; C:protein complex; IEA:Compara. 
Interpro
 IPR011044; Quino_amine_DH_bsu.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS