UniProt Accession

 TPM3_RAT; Q63610; Q63599; Q63600; Q63601 

Genbank Protein ID

 L24775; L24776; L24777; X72859 

Genbank Nucleotide ID

 AAA21721.1; AAA42263.1; AAA42264.1; CAA51382.1 

Protein Name

 Tropomyosin alpha-3 chain 

Protein Synonyms/Alias

 Gamma-tropomyosin; Tropomyosin-3; Tropomyosin-5 

Gene Name

 Tpm3 

Gene Synonyms/Alias

 Tpm-5; Tpm5 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
11	STTIEAVKRKIQVLQ	acetylation	[1]
13	TIEAVKRKIQVLQQQ	acetylation	[1]
100	VIENRALKDEEKMEL	acetylation	[1]
104	RALKDEEKMELQEIQ	acetylation	[1]
190	DKYEEEIKILTDKLK	acetylation	[1]
215	RSVAKLEKTIDDLED	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.  

Keyword

 Acetylation; Actin-binding; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Muscle protein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 248 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0007420; P:brain development; IEP:RGD. 

Interpro

 IPR000533; Tropomyosin. 

Pfam

 PF00261; Tropomyosin 

SMART

  

PROSITE

 PS00326; TROPOMYOSIN 

PRINTS

 PR00194; TROPOMYOSIN.