UniProt Accession

 FOXK2_HUMAN; Q01167; A6NEP5; Q13622; Q13623; Q13624 

Genbank Protein ID

 X60787; U58196; U58197; U58198; AC124287 

Genbank Nucleotide ID

 CAA43200.1; AAB02820.1; AAB02821.1; AAB02822.1 

Protein Name

 Forkhead box protein K2 

Protein Synonyms/Alias

 Cellular transcription factor ILF-1; FOXK1; Interleukin enhancer-binding factor 1 

Gene Name

 FOXK2 

Gene Synonyms/Alias

 ILF; ILF1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
118	FYLRCLGKNGVFVDG	ubiquitination	[1]
318	SLNRYFIKVPRSQEE	ubiquitination	[1]
328	RSQEEPGKGSFWRID	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Recognizes the core sequence 5'-TAAACA-3'. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter. Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements. 

Sequence Annotation

 DOMAIN 54 128 FHA.
 DNA_BIND 258 353 Fork-head.
 REGION 300 318 DNA-binding; major groove.
 REGION 328 332 DNA-binding; minor groove.
 REGION 348 353 DNA-binding; minor groove.
 METAL 310 310 Magnesium; via carbonyl oxygen.
 METAL 311 311 Magnesium; via carbonyl oxygen.
 METAL 313 313 Magnesium; via carbonyl oxygen.
 METAL 316 316 Magnesium; via carbonyl oxygen.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 30 30 Phosphoserine.
 MOD_RES 239 239 Phosphoserine.
 MOD_RES 398 398 Phosphoserine.
 MOD_RES 424 424 Phosphoserine.
 MOD_RES 428 428 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; DNA-binding; Magnesium; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 660 AA 

Protein Sequence

Gene Ontology

 GO:0005667; C:transcription factor complex; IBA:RefGenome.
 GO:0008301; F:DNA binding, bending; IBA:RefGenome.
 GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.
 GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
 GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
 GO:0008134; F:transcription factor binding; IBA:RefGenome.
 GO:0009790; P:embryo development; IBA:RefGenome.
 GO:0007389; P:pattern specification process; IBA:RefGenome.
 GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
 GO:0009888; P:tissue development; IBA:RefGenome. 

Interpro

 IPR000253; FHA_dom.
 IPR008984; SMAD_FHA_domain.
 IPR001766; TF_fork_head.
 IPR018122; TF_fork_head_CS.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00498; FHA
 PF00250; Fork_head 

SMART

 SM00339; FH
 SM00240; FHA 

PROSITE

 PS50006; FHA_DOMAIN
 PS00657; FORK_HEAD_1
 PS00658; FORK_HEAD_2
 PS50039; FORK_HEAD_3 

PRINTS

 PR00053; FORKHEAD.