UniProt Accession

 RIHA_ECOLI; P41409; P77738 

Genbank Protein ID

 U82598; U00096; AP009048; U10981 

Genbank Nucleotide ID

 AAB40852.1; AAC73752.1; BAA35303.1 

Protein Name

 Pyrimidine-specific ribonucleoside hydrolase RihA 

Protein Synonyms/Alias

 Cytidine/uridine-specific hydrolase 

Gene Name

 rihA 

Gene Synonyms/Alias

 ybeK; b0651; JW0646 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
44	AGNQTPEKTLRNVLR	acetylation	[1, 2]

Reference

 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively. 

Sequence Annotation

 ACT_SITE 240 240 By similarity.  

Keyword

 3D-structure; Complete proteome; Glycosidase; Hydrolase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 311 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005509; F:calcium ion binding; IDA:EcoCyc.
 GO:0047405; F:pyrimidine-5'-nucleotide nucleosidase activity; IDA:EcoliWiki.
 GO:0045437; F:uridine nucleosidase activity; IDA:EcoCyc.
 GO:0015949; P:nucleobase-containing small molecule interconversion; IEA:InterPro.
 GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:HAMAP.
 GO:0046133; P:pyrimidine ribonucleoside catabolic process; IMP:EcoCyc. 

Interpro

 IPR015910; I/U_nuclsd_hydro_CS.
 IPR023186; Inosine/uridine_hydrolase.
 IPR001910; Inosine/uridine_hydrolase_dom.
 IPR022975; Pyrim_hydro_RihA. 

Pfam

 PF01156; IU_nuc_hydro 

SMART

  

PROSITE

 PS01247; IUNH 

PRINTS