UniProt Accession

 MOSC2_MOUSE; Q922Q1 

Genbank Protein ID

 AK051230; BC006888 

Genbank Nucleotide ID

 BAC34565.1; AAH06888.1 

Protein Name

 MOSC domain-containing protein 2, mitochondrial 

Protein Synonyms/Alias

 Mitochondrial amidoxime reducing component 2; mARC1; Moco sulfurase C-terminal domain-containing protein 2; Molybdenum cofactor sulfurase C-terminal domain-containing protein 2 

Gene Name

 Marc2 

Gene Synonyms/Alias

 Mg87; Mosc2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
59	QQVGTVSKVWIYPIK	ubiquitination	[1]
66	KVWIYPIKSCKGVSV	acetylation	[2]
66	KVWIYPIKSCKGVSV	ubiquitination	[1]
69	IYPIKSCKGVSVCET	ubiquitination	[1]
97	DRFWMVVKEDGHMVT	acetylation	[2]
97	DRFWMVVKEDGHMVT	ubiquitination	[1]
144	IKLPSSNKIHNCRLF	ubiquitination	[1]
156	RLFGLDIKGRDCGDE	acetylation	[2]
156	RLFGLDIKGRDCGDE	ubiquitination	[1]
187	VQFDTSMKGRTTKKL	ubiquitination	[1]
289	DTGIIDRKEPLETLK	acetylation	[2]
289	DTGIIDRKEPLETLK	ubiquitination	[1]
296	KEPLETLKSYRLCDP	acetylation	[2]
296	KEPLETLKSYRLCDP	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 As a component of the benzamidoxime prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively (By similarity). 

Sequence Annotation

 DOMAIN 188 336 MOSC.  

Keyword

 Complete proteome; Membrane; Mitochondrion; Mitochondrion outer membrane; Molybdenum; Oxidoreductase; Peroxisome; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 338 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
 GO:0030151; F:molybdenum ion binding; IEA:Compara.
 GO:0043546; F:molybdopterin cofactor binding; IEA:Compara.
 GO:0008940; F:nitrate reductase activity; IEA:Compara.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0042126; P:nitrate metabolic process; IEA:Compara. 

Interpro

 IPR005302; MoCF_Sase_C.
 IPR005303; MOSC_N.
 IPR011037; Pyrv_Knase-like_insert_dom. 

Pfam

 PF03473; MOSC
 PF03476; MOSC_N 

SMART

  

PROSITE

 PS51340; MOSC 

PRINTS