| Tag | Content |
|---|
| CPLM ID | CPLM-007174 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Mitochondrial Rho GTPase 1 |
Protein Synonyms/Alias | GTPase EF-hand protein of mitochondria 1 |
Gene Name | GEM1 |
Gene Synonyms/Alias | YAL048C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 482 | EEYSPTIKPRIAVNS | ubiquitination | [1] | | 493 | AVNSLELKGGKQYYL | ubiquitination | [1] | | 566 | ASKADLDKQQQRCQI | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (Probable). |
Sequence Annotation | DOMAIN 1 140 Miro 1.
DOMAIN 201 236 EF-hand 1.
DOMAIN 330 365 EF-hand 2.
DOMAIN 442 662 Miro 2.
NP_BIND 12 19 GTP 1 (Probable).
NP_BIND 62 64 GTP 1 (Potential).
NP_BIND 116 119 GTP 1 (Potential).
NP_BIND 455 462 GTP 2 (Probable).
NP_BIND 491 495 GTP 2 (Potential).
NP_BIND 560 563 GTP 2 (Potential). |
Keyword | Calcium; Complete proteome; GTP-binding; Hydrolase; Membrane; Metal-binding; Mitochondrion; Mitochondrion outer membrane; Nucleotide-binding; Reference proteome; Repeat; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 662 AA |
Protein Sequence | MTKETIRVVI CGDEGVGKSS LIVSLTKAEF IPTIQDVLPP ISIPRDFSSS PTYSPKNTVL 60
IDTSDSDLIA LDHELKSADV IWLVYCDHES YDHVSLFWLP HFRSLGLNIP VILCKNKCDS 120
ISNVNANAMV VSENSDDDID TKVEDEEFIP ILMEFKEIDT CIKTSAKTQF DLNQAFYLCQ 180
RAITHPISPL FDAMVGELKP LAVMALKRIF LLSDLNQDSY LDDNEILGLQ KKCFNKSIDV 240
NELNFIKDLL LDISKHDQEY INRKLYVPGK GITKDGFLVL NKIYAERGRH ETTWAILRTF 300
HYTDSLCIND KILHPRLVVP DTSSVELSPK GYRFLVDIFL KFDIDNDGGL NNQELHRLFK 360
CTPGLPKLWT STNFPFSTVV NNKGCITLQG WLAQWSMTTF LNYSTTTAYL VYFGFQEDAR 420
LALQVTKPRK MRRRSGKLYR SNINDRKVFN CFVIGKPCCG KSSLLEAFLG RSFSEEYSPT 480
IKPRIAVNSL ELKGGKQYYL ILQELGEQEY AILENKDKLK ECDVICLTYD SSDPESFSYL 540
VSLLDKFTHL QDLPLVFVAS KADLDKQQQR CQIQPDELAD ELFVNHPLHI SSRWLSSLNE 600
LFIKITEAAL DPGKNTPGLP EETAAKDVDY RQTALIFGST VGFVALCSFT LMKLFKSSKF 660
SK 662 |
Gene Ontology | GO:0032865; C:ERMES complex; IPI:SGD. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005509; F:calcium ion binding; IDA:SGD. GO:0005525; F:GTP binding; IEA:UniProtKB-KW. GO:0003924; F:GTPase activity; IDA:SGD. GO:0019725; P:cellular homeostasis; IEA:InterPro. GO:0000001; P:mitochondrion inheritance; IMP:SGD. GO:0055091; P:phospholipid homeostasis; IGI:SGD. GO:0010821; P:regulation of mitochondrion organization; IMP:SGD. GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |