UniProt Accession

 PAR6A_HUMAN; Q9NPB6; O14911; Q9NPJ7 

Genbank Protein ID

 AJ277095; AF265565; AF252292; AB043634; AB041642; BC015626; AF028827 

Genbank Nucleotide ID

 CAB85490.1; AAF75548.1; AAF71529.1; BAA96235.1; BAB16105.1; AAH15626.1; AAB84252.1 

Protein Name

 Partitioning defective 6 homolog alpha 

Protein Synonyms/Alias

 PAR-6; PAR-6 alpha; PAR-6A; PAR6C; Tax interaction protein 40; TIP-40 

Gene Name

 PARD6A 

Gene Synonyms/Alias

 PAR6A 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
19	PDSIVEVKSKFDAEF	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. 

Sequence Annotation

 DOMAIN 15 95 OPR.
 DOMAIN 133 150 Pseudo-CRIB.
 DOMAIN 157 250 PDZ.
 REGION 1 116 Interaction with PRKCI and PRKCZ.
 REGION 126 253 Interaction with PARD3 and CDC42 (By
 MOD_RES 278 278 Phosphoserine.  

Keyword

 3D-structure; Alternative splicing; Cell cycle; Cell division; Cell junction; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Tight junction. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 346 AA 

Protein Sequence

Gene Ontology

 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0005938; C:cell cortex; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
 GO:0005923; C:tight junction; ISS:UniProtKB.
 GO:0030742; F:GTP-dependent protein binding; ISS:UniProtKB.
 GO:0017048; F:Rho GTPase binding; ISS:UniProtKB.
 GO:0008134; F:transcription factor binding; TAS:ProtInc.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0045217; P:cell-cell junction maintenance; ISS:UniProtKB.
 GO:0070830; P:tight junction assembly; TAS:Reactome.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:Reactome.
 GO:0016032; P:viral reproduction; TAS:ProtInc. 

Interpro

 IPR000270; OPR_PB1.
 IPR001478; PDZ. 

Pfam

 PF00564; PB1
 PF00595; PDZ 

SMART

 SM00666; PB1
 SM00228; PDZ 

PROSITE

 PS50106; PDZ 

PRINTS