CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042402
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Anaphase-promoting complex subunit 1 
Protein Synonyms/Alias
  
Gene Name
 ANAPC1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
100PELRDSSKLHDSLYNubiquitination[1, 2]
229LSPVIAPKKARPSETubiquitination[3]
230SPVIAPKKARPSETGubiquitination[2]
440RITIAPQKLQVEQEEubiquitination[1, 2, 3, 4, 5]
520IGRQDLSKQACEGNLubiquitination[1, 2, 5, 6]
531EGNLPKGKSVLSSDVubiquitination[1]
601DHEFIEEKENRLLQLubiquitination[1, 2, 3, 5]
697SAWIVYNKPKHAELAubiquitination[2, 5]
1183TQWYEQTKEELMAPTubiquitination[1, 2]
1228HLKSILSKDGVLYVKubiquitination[2]
1235KDGVLYVKLRAGQLSubiquitination[2]
1244RAGQLSYKEDPMGWQubiquitination[1, 2, 3, 4, 5]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1452 AA 
Protein Sequence
XIFGSVTNIP AKDAAPVEKI DTMLVLEGSG NLVLYTGVVR VGKVFIPGLP APSLTMSNTM 60
PRPSTPLDGV STPKPLSKLL GSLDEVVLLS PVPELRDSSK LHDSLYNEDC TFQQLGTYIH 120
SIRDPVHNRV TLELSNGSMV RITIPEIATS ELVQTCLQAI KFILPKEIAV QMLVKWYNVH 180
SAPGGPSYHS EWNLFVTCLM NMMGYNTDRL AWTRNFDFEG SLSPVIAPKK ARPSETGSDD 240
DWEYLLNSDY HQNVESHLLN RSLCLSPSEA SQMKDEDFSQ NLSLDSSTLL FTHIPAIFFV 300
LHLVYEELKL NTLMGEGICS LVELLVQLAR DLKLGPYVDH YYRDYPTLVR TTGQVCTIDP 360
GQTGFMHHPS FFTSEPPSIY QWVSSCLKGE GMPPYPYLPG ICERSRLVVL SIALYILGDE 420
SLVSDESSQY LTRITIAPQK LQVEQEENRF SFRHSTSVSS LAERLVVWMT NVGFTLRDLE 480
TLPFGIALPI RDAIYHCREQ PASDWPEAVC LLIGRQDLSK QACEGNLPKG KSVLSSDVPS 540
GTETEEEDDG MNDMNHEVMS LIWSEDLRVQ DVRRLLQSAH PVRVNVVQYP ELSDHEFIEE 600
KENRLLQLCQ RTMALPVGRG MFTLFSYHPV PTEPLPIPKL NLTGRAPPRN TTVDLNSGNI 660
DVPPNMTSWA SFHNGVAAGL KIAPASQIDS AWIVYNKPKH AELANEYAGF LMALGLNGHL 720
TKLATLNIHD YLTKGHEMTS IGLLLGVSAA KLGTMDMSIT RLLSIHIPAL LPPTSTELDV 780
PHNVQVAAVV GIGLVYQGTA HRHTAEVLLA EIGRPPGPEM EYCTDRESYS LAAGLALGMV 840
CLGHGSNLIG MSDLNVPEQL YQYMVGGHRR FQTGMHREKH KSPSYQIKEG DTINVDVTCP 900
GATLALAMIY LKTNNRSIAD WLRAPDTMYL LDFVKPEFLL LRTLARCLIL WDDILPNSKW 960
VDSNVPQIIR ENSISLSEIE LPCSEDLNLE TLSQAHVYII AGACLSLGFR FAGSENLSAF 1020
NCLHKFAKDF MTYLSAPNAS VTGPHNLETC LSVVLLSLAM VMAGSGNLKV LQLCRFLHMK 1080
TGGEMNYGFH LAHHMALGLL FLGGGRYSLS TSNSSIAALL CALYPHFPAH STDNRYHLQA 1140
LRHLYVLAAE PRLLVPVDVD TNTPCYALLE VTYKGTQWYE QTKEELMAPT LLPELHLLKQ 1200
IKVKGPRYWE LLIDLSKGTQ HLKSILSKDG VLYVKLRAGQ LSYKEDPMGW QSLLAQTVAN 1260
RNSEARAFKP ETISAFTSDP ALLSFAEYFC KPTVNMGQKQ EILDLFSSVL YECVTQETPE 1320
MLPAYIAMDQ AIRRLGRREM SETSELWQIK LVLEFFSSRS HQERLQNHPK RGLFMNSEFL 1380
PVVKCTIDNT LDQWLQVGGD MCVHAYLSGQ PLEESQLSML ACFLVYHSVP APQHLPPIGL 1440
EGLLKDLAGD SG 1452 
Gene Ontology
 GO:0005680; C:anaphase-promoting complex; IEA:InterPro. 
Interpro
 IPR024990; Apc1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS