CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003963
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Steroid 17-alpha-hydroxylase/17,20 lyase 
Protein Synonyms/Alias
 17-alpha-hydroxyprogesterone aldolase; CYPXVII; Cytochrome P450 17A1; Cytochrome P450-C17; Cytochrome P450c17 
Gene Name
 Cyp17a1 
Gene Synonyms/Alias
 Cyp17 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
88LAREVLIKKGKEFSGacetylation[1]
91EVLIKKGKEFSGRPQacetylation[1]
136FSTFSLFKDGQKLEKacetylation[1]
193SYEKNDPKLTAIKTFacetylation[1]
329EVKKKIQKEIDQYVGacetylation[1]
489VFLIDPFKVKITVRQacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty. 
Sequence Annotation
 METAL 441 441 Iron (heme axial ligand) (By similarity).  
Keyword
 Complete proteome; Direct protein sequencing; Heme; Iron; Lyase; Membrane; Metal-binding; Monooxygenase; Oxidoreductase; Reference proteome; Steroidogenesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 507 AA 
Protein Sequence
MWELVGLLLL ILAYFFWVKS KTPGAKLPRS LPSLPLVGSL PFLPRRGHMH VNFFKLQEKY 60
GPIYSLRLGT TTTVIIGHYQ LAREVLIKKG KEFSGRPQMV TQSLLSDQGK GVAFADAGSS 120
WHLHRKLVFS TFSLFKDGQK LEKLICQEAK SLCDMMLAHD KESIDLSTPI FMSVTNIICA 180
ICFNISYEKN DPKLTAIKTF TEGIVDATGD RNLVDIFPWL TIFPNKGLEV IKGYAKVRNE 240
VLTGIFEKCR EKFDSQSISS LTDILIQAKM NSDNNNSCEG RDPDVFSDRH ILATVGDIFG 300
AGIETTTTVL KWILAFLVHN PEVKKKIQKE IDQYVGFSRT PTFNDRSHLL MLEATIREVL 360
RIRPVAPMLI PHKANVDSSI GEFTVPKDTH VVVNLWALHH DENEWDQPDQ FMPERFLDPT 420
GSHLITPTQS YLPFGAGPRS CIGEALARQE LFVFTALLLQ RFDLDVSDDK QLPRLEGDPK 480
VVFLIDPFKV KITVRQAWMD AQAEVST 507 
Gene Ontology
 GO:0030424; C:axon; IEA:Compara.
 GO:0042995; C:cell projection; IDA:RGD.
 GO:0005783; C:endoplasmic reticulum; IDA:RGD.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0047442; F:17-alpha-hydroxyprogesterone aldolase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; ISS:UniProtKB.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0004508; F:steroid 17-alpha-monooxygenase activity; IDA:RGD.
 GO:0030325; P:adrenal gland development; IEP:RGD.
 GO:0006702; P:androgen biosynthetic process; TAS:RGD.
 GO:0018879; P:biphenyl metabolic process; IEP:RGD.
 GO:0071236; P:cellular response to antibiotic; IEP:RGD.
 GO:0071371; P:cellular response to gonadotropin stimulus; IEP:RGD.
 GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.
 GO:0018894; P:dibenzo-p-dioxin metabolic process; IEP:RGD.
 GO:0006704; P:glucocorticoid biosynthetic process; IEA:Compara.
 GO:0021766; P:hippocampus development; IEP:RGD.
 GO:0033327; P:Leydig cell differentiation; IEP:RGD.
 GO:0030728; P:ovulation; IEP:RGD.
 GO:0018958; P:phenol-containing compound metabolic process; IEP:RGD.
 GO:0018963; P:phthalate metabolic process; IEP:RGD.
 GO:0090031; P:positive regulation of steroid hormone biosynthetic process; IMP:RGD.
 GO:0042448; P:progesterone metabolic process; ISS:UniProtKB.
 GO:0010034; P:response to acetate; IEP:RGD.
 GO:0051591; P:response to cAMP; IEP:RGD.
 GO:0034097; P:response to cytokine stimulus; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0060992; P:response to fungicide; IEP:RGD.
 GO:0009635; P:response to herbicide; IEP:RGD.
 GO:0017085; P:response to insecticide; IEP:RGD.
 GO:0010212; P:response to ionizing radiation; IEP:RGD.
 GO:0051597; P:response to methylmercury; IEP:RGD.
 GO:0031667; P:response to nutrient levels; IEP:RGD.
 GO:0032526; P:response to retinoic acid; IEP:RGD.
 GO:0048545; P:response to steroid hormone stimulus; IEP:RGD. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00463; EP450I.
 PR00385; P450.