CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003726
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein COS2 
Protein Synonyms/Alias
  
Gene Name
 COS2 
Gene Synonyms/Alias
 YBR302C; YBR2121 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
10ENELKNEKSVDVLSFubiquitination[1]
18SVDVLSFKQLESQKIubiquitination[1, 2, 3, 4]
205WKLFNTEKSWSPVGLubiquitination[1, 2, 3, 5]
216PVGLEDAKLPKEAYRubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery.
 Hitchcock AL, Auld K, Gygi SP, Silver PA.
 Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12735-40. [PMID: 14557538]
 [3] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269]
 [4] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [5] Computational identification of ubiquitylation sites from protein sequences.
 Tung CW, Ho SY.
 BMC Bioinformatics. 2008 Jul 15;9:310. [PMID: 18625080
Functional Description
  
Sequence Annotation
 CROSSLNK 18 18 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 205 205 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Complete proteome; Isopeptide bond; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 379 AA 
Protein Sequence
MKENELKNEK SVDVLSFKQL ESQKIVLPQD LFRSSFTWFC YEIYKSLAFR IWMLLWLPLS 60
VWWKLSNNCI YPLIVSLLVL FLGPIFVLVI CGLSRKRSLS KQLIQFCKEI TENTPSSDPH 120
DWEVVAANLN SYLYENNVWN TKYFFFNAMV CQEAFRTTLL EPFSLKKDKA AKVKSFKDSV 180
PYIEEALGVY FTEVEKQWKL FNTEKSWSPV GLEDAKLPKE AYRFKLTWFL KRISNIFMLI 240
PFLNFLCCIY VSRGMCLLLR TLYLGWILFM LVQGFQNIRV LIMSMEHKMQ FLSTIINEQE 300
SGANGWDEIA RKMNRYLFEK KAWKNEEFFF DGIDCEWFFN HFFYRVLSAK KSMWPLPLNV 360
ELWPYIKEAQ LSRSEVLLV 379 
Gene Ontology
 GO:0000324; C:fungal-type vacuole; IDA:SGD.
 GO:0016021; C:integral to membrane; ISM:SGD. 
Interpro
 IPR001142; DUP. 
Pfam
 PF00674; DUP 
SMART
  
PROSITE
  
PRINTS