| Tag | Content |
|---|
| CPLM ID | CPLM-010274 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 3-ketoacyl-CoA thiolase |
Protein Synonyms/Alias | ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta |
Gene Name | fadI |
Gene Synonyms/Alias | yfcY; b2342; JW2339 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 149 | RVLVDVNKARTMSQR | acetylation | [1] | | 235 | TAFIPPYKQPLVEDN | acetylation | [1] | | 255 | SSLADYAKLRPAFDR | acetylation | [1] | | 380 | TGEVDDSKFNVLGGS | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Strongly involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate and weakly involved in the aerobic degradation of long- chain fatty acids. |
Sequence Annotation | ACT_SITE 99 99 Acyl-thioester intermediate (By
ACT_SITE 392 392 Proton acceptor (By similarity).
ACT_SITE 422 422 Proton acceptor (By similarity). |
Keyword | Acyltransferase; Complete proteome; Cytoplasm; Fatty acid metabolism; Lipid degradation; Lipid metabolism; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 436 AA |
Protein Sequence | MGQVLPLVTR QGDRIAIVSG LRTPFARQAT AFHGIPAVDL GKMVVGELLA RSEIPAEVIE 60
QLVFGQVVQM PEAPNIAREI VLGTGMNVHT DAYSVSRACA TSFQAVANVA ESLMAGTIRA 120
GIAGGADSSS VLPIGVSKKL ARVLVDVNKA RTMSQRLKLF SRLRLRDLMP VPPAVAEYST 180
GLRMGDTAEQ MAKTYGITRE QQDALAHRSH QRAAQAWSDG KLKEEVMTAF IPPYKQPLVE 240
DNNIRGNSSL ADYAKLRPAF DRKHGTVTAA NSTPLTDGAA AVILMTESRA KELGLVPLGY 300
LRSYAFTAID VWQDMLLGPA WSTPLALERA GLTMSDLTLI DMHEAFAAQT LANIQLLGSE 360
RFAREALGRA HATGEVDDSK FNVLGGSIAY GHPFAATGAR MITQTLHELR RRGGGFGLVT 420
ACAAGGLGAA MVLEAE 436 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:EcoliWiki. GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IDA:EcoliWiki. GO:0003988; F:acetyl-CoA C-acyltransferase activity; IDA:EcoliWiki. GO:0004300; F:enoyl-CoA hydratase activity; IDA:EcoliWiki. GO:0033542; P:fatty acid beta-oxidation, unsaturated, even number; IMP:EcoliWiki. |
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PRINTS | |