CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021963
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Carbohydrate sulfotransferase 11 
Protein Synonyms/Alias
 Chondroitin 4-O-sulfotransferase 1; Chondroitin 4-sulfotransferase 1; C4S-1; C4ST-1; C4ST1 
Gene Name
 CHST11 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
2******MKPALLEVMubiquitination[1]
143MVLTGRGKYSDPMEIubiquitination[1]
210KYNISFHKRYGTKIIubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6- di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor. 
Sequence Annotation
 NP_BIND 124 130 PAPS (By similarity).
 NP_BIND 186 194 PAPS (By similarity).
 CARBOHYD 205 205 N-linked (GlcNAc...) (Potential).
 CARBOHYD 223 223 N-linked (GlcNAc...) (Potential).
 CARBOHYD 321 321 N-linked (GlcNAc...) (Potential).
 CARBOHYD 342 342 N-linked (GlcNAc...) (Probable).  
Keyword
 Alternative splicing; Carbohydrate metabolism; Chromosomal rearrangement; Complete proteome; Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 352 AA 
Protein Sequence
MKPALLEVMR MNRICRMVLA TCLGSFILVI FYFQSMLHPV MRRNPFGVDI CCRKGSRSPL 60
QELYNPIQLE LSNTAVLHQM RRDQVTDTCR ANSATSRKRR VLTPNDLKHL VVDEDHELIY 120
CYVPKVACTN WKRLMMVLTG RGKYSDPMEI PANEAHVSAN LKTLNQYSIP EINHRLKSYM 180
KFLFVREPFE RLVSAYRNKF TQKYNISFHK RYGTKIIKRQ RKNATQEALR KGDDVKFEEF 240
VAYLIDPHTQ REEPFNEHWQ TVYSLCHPCH IHYDLVGKYE TLEEDSNYVL QLAGVGSYLK 300
FPTYAKSTRT TDEMTTEFFQ NISSEHQTQL YEVYKLDFLM FNYSVPSYLK LE 352 
Gene Ontology
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0047756; F:chondroitin 4-sulfotransferase activity; IDA:UniProtKB.
 GO:0001537; F:N-acetylgalactosamine 4-O-sulfotransferase activity; IDA:UniProtKB.
 GO:0050659; F:N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity; IEA:Compara.
 GO:0016051; P:carbohydrate biosynthetic process; IEA:InterPro.
 GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.
 GO:0002063; P:chondrocyte development; IEA:Compara.
 GO:0030206; P:chondroitin sulfate biosynthetic process; IDA:UniProtKB.
 GO:0048589; P:developmental growth; IEA:Compara.
 GO:0042733; P:embryonic digit morphogenesis; IEA:Compara.
 GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Compara.
 GO:0033037; P:polysaccharide localization; IEA:Compara.
 GO:0036342; P:post-anal tail morphogenesis; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0042127; P:regulation of cell proliferation; IEA:Compara.
 GO:0007585; P:respiratory gaseous exchange; IEA:Compara. 
Interpro
 IPR018011; Carb_sulfotransferase-rel.
 IPR005331; Sulfotransferase. 
Pfam
 PF03567; Sulfotransfer_2 
SMART
  
PROSITE
  
PRINTS