| Tag | Content |
|---|
| CPLM ID | CPLM-015463 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dual serine/threonine and tyrosine protein kinase |
Protein Synonyms/Alias | Dusty protein kinase; Dusty PK; Receptor-interacting serine/threonine-protein kinase 5 |
Gene Name | Dstyk |
Gene Synonyms/Alias | Ripk5 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 578 | IDSLSASKLAKSICS | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | May induce both caspase-dependent apoptosis and caspase- independent cell death (By similarity). |
Sequence Annotation | DOMAIN 650 904 Protein kinase.
NP_BIND 656 664 ATP (By similarity).
ACT_SITE 775 775 Proton acceptor (By similarity).
BINDING 679 679 ATP (By similarity). |
Keyword | ATP-binding; Coiled coil; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 927 AA |
Protein Sequence | MEADGQSWSG ESVSGPGPGG GGMIRELCRG FGRYRRYLGR LRQNLRETQK FFRDIKCSHS 60
HSCPSSPAGG GAAELGPAGD VAAAPLPAGQ LSCISFPPME EKYLQQIVDH LPCILILGQD 120
CNAKCQLLNL LLAVRVLPTL KLDSDESCKL RRLRFTYGTR TQVSLALPGQ YELVHTLASH 180
QDNWETIPEE DLEVQEDSED TARVLADLEV TMHHALLQEV DIVVAPCHSH RPAVDVLSDL 240
ANDFLPVITY ALHKDELSER DEQELQEIRK YFSFPVFFFK VPTLEIIRSS SGRADSERSP 300
LSGQLMDLGY LSSSHRNCMA SDQDCRAQSM LVEQSEKLRQ LSTFSHQLLQ TRLVDAAKAL 360
NAVHSHCLDI FINQAFDMQR DLQITPKRLE YTRKKENELY ESLMNIANRK QEEMKDMIVE 420
TLNTMKEELL DDAANMEFKD VIVPENGETV GTREIKSCIR QIQELIISRL NQAVANKLIS 480
SVDYLRESFV GTLERCLQSL EKSQDVSVHI TSNYLKQILN AAYHVEVTFH SGSSVTRMLW 540
EQIKQIIQRI TWVNPPTITL EWKRKVAQEA IDSLSASKLA KSICSQFRTR LNSSHEAFAA 600
SLRQLEAGHS GRLEKTEDLW LKVRKDHAPR LARLSLESRS LQDVLLHRKP KLGQELGRGQ 660
YGVVYLCDNW GGHFPCALKS VVPPDEKHWN DLALEFHYMR SLPKHERLVD LHGSVIDYNY 720
GGGSSVAVLL IMERLHRDLY TGLKAGLSLE TRLQIALDVV EGIRFLHSQG LVHRDIKLKN 780
VLLDKQNRAK ITDLGFCKPE AMMSGSIVGT PIHMAPELFT GKYDNSVDVY AFGILFWYIC 840
SGSIKLPEAF ERCASKDHLW NNVRRGTRPE RLPVFDEECW QLMEACWDGD PSKRPLLGIV 900
QPILRSIMDR LCKCDSERPS RGLDDST 927 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0045111; C:intermediate filament cytoskeleton; IEA:Compara. GO:0005634; C:nucleus; IEA:Compara. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:EC. GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |