CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032010
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glucosamine-6-phosphate isomerase 1 
Protein Synonyms/Alias
 cDNA FLJ55085, highly similar to Glucosamine-6-phosphate isomerase (EC 3.5.99.6) 
Gene Name
 GNPDA1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
50STPLGCYKKLIEYYKubiquitination[1]
51TPLGCYKKLIEYYKNubiquitination[2, 3]
57KKLIEYYKNGDLSFKubiquitination[2]
64KNGDLSFKYVKTFNEacetylation[3]
83LVSRTRVKTLAMDTIubiquitination[2, 3]
176ELKVKTVKYFKGLMLubiquitination[2]
179VKTVKYFKGLMLVHNubiquitination[1, 2, 4]
187GLMLVHNKLVDPLYSubiquitination[1, 2, 4]
196VDPLYSIKEKETEKSubiquitination[5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Isomerase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 212 AA 
Protein Sequence
MKLIILEHYS QASEWAAKYI RNRIIQFNPG PEKYFTLGLP TGSTPLGCYK KLIEYYKNGD 60
LSFKYVKTFN EPGSSLVSRT RVKTLAMDTI LANARFFDGE LTKVPTMALT VGVGTVMDAR 120
EVMILITGAH KAFALYKAIE EGVNHMWTVS AFQQHPRTVF VCDEDATLEL KVKTVKYFKG 180
LMLVHNKLVD PLYSIKEKET EKSQSSKKPY SD 212 
Gene Ontology
 GO:0004342; F:glucosamine-6-phosphate deaminase activity; IEA:InterPro.
 GO:0006044; P:N-acetylglucosamine metabolic process; IEA:InterPro. 
Interpro
 IPR004547; Glucosamine6P_isomerase. 
Pfam
  
SMART
  
PROSITE
  
PRINTS