UniProt Accession

 IFIT2_HUMAN; P09913; Q5T767 

Genbank Protein ID

 M14660; M14659; AL353751; X07557 

Genbank Nucleotide ID

 AAA59191.1; AAA59191.1; CAI12238.1; CAA30438.1 

Protein Name

 Interferon-induced protein with tetratricopeptide repeats 2 

Protein Synonyms/Alias

 IFIT-2; ISG-54 K; Interferon-induced 54 kDa protein; IFI-54K; P54 

Gene Name

 IFIT2 

Gene Synonyms/Alias

 CIG-42; G10P2; IFI54; ISG54 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
6	**MSENNKNSLESSL	ubiquitination	[1]
64	LAYLKHLKGQNEAAL	ubiquitination	[1]
163	RAKVCFEKALEKKPK	ubiquitination	[1]
212	NPDNQYLKVLLALKL	ubiquitination	[1]
325	HAVAHLKKADEANDN	ubiquitination	[1]
370	KELTPVAKQLLHLRY	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis. 

Sequence Annotation

 REPEAT 51 89 TPR 1.
 REPEAT 90 135 TPR 2.
 REPEAT 136 171 TPR 3.
 REPEAT 172 208 TPR 4.
 REPEAT 247 280 TPR 5.
 REPEAT 281 335 TPR 6.
 REPEAT 336 366 TPR 7.
 REPEAT 367 405 TPR 8.
 REPEAT 406 448 TPR 9.  

Keyword

 3D-structure; Antiviral defense; Apoptosis; Complete proteome; Cytoplasm; Endoplasmic reticulum; Immunity; Innate immunity; Polymorphism; Reference proteome; Repeat; RNA-binding; TPR repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 472 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0008637; P:apoptotic mitochondrial changes; TAS:UniProtKB.
 GO:0035457; P:cellular response to interferon-alpha; IEA:Compara.
 GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
 GO:0032091; P:negative regulation of protein binding; IDA:BHF-UCL.
 GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
 GO:0009615; P:response to virus; IMP:UniProtKB.
 GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome. 

Interpro

 IPR024124; Interferon-induced_IFIT2.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 

Pfam

 PF13181; TPR_8 

SMART

 SM00028; TPR 

PROSITE

 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS