UniProt Accession

 AK1A1_HUMAN; P14550; A8KAL8; D3DQ04; Q6IAZ4 

Genbank Protein ID

 J04794; AF036683; AF036680; AF036681; AF036682; AF112485; AF112484; AK293083; CR457010; BT007003; AL355480; CH471059; CH471059; CH471059; CH471059; BC000670; BC005394 

Genbank Nucleotide ID

 AAA51711.1; AAB92369.1; AAB92369.1; AAB92369.1; AAB92369.1; AAF01260.1; AAF01260.1; BAF85772.1; CAG33291.1; AAP35649.1; CAI22459.1; EAX06970.1; EAX06971.1; EAX06972.1; EAX06974.1; AAH00670.1; AAH05394.1 

Protein Name

 Alcohol dehydrogenase [NADP(+)] 

Protein Synonyms/Alias

 Aldehyde reductase; Aldo-keto reductase family 1 member A1 

Gene Name

 AKR1A1 

Gene Synonyms/Alias

 ALDR1; ALR 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
13	VLLHTGQKMPLIGLG	ubiquitination	[1]
23	LIGLGTWKSEPGQVK	ubiquitination	[1, 2, 3]
68	KEDVGPGKAVPREEL	ubiquitination	[2]
80	EELFVTSKLWNTKHH	ubiquitination	[2]
85	TSKLWNTKHHPEDVE	ubiquitination	[1]
127	RGDNPFPKNADGTIC	acetylation	[4]
141	CYDSTHYKETWKALE	ubiquitination	[1]
153	ALEALVAKGLVQALG	ubiquitination	[2]
287	TFSPEEMKQLNALNK	ubiquitination	[1, 2, 3]
308	PMLTVDGKRVPRDAG	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). 

Sequence Annotation

 NP_BIND 211 273 NADP (By similarity).
 ACT_SITE 50 50 Proton donor.
 BINDING 113 113 Substrate.
 MOD_RES 2 2 N-acetylalanine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; NADP; Oxidoreductase; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 325 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; TAS:ProtInc.
 GO:0009055; F:electron carrier activity; TAS:UniProtKB.
 GO:0047939; F:L-glucuronate reductase activity; IEA:Compara.
 GO:0046185; P:aldehyde catabolic process; IEA:Compara.
 GO:0006081; P:cellular aldehyde metabolic process; TAS:ProtInc.
 GO:0042840; P:D-glucuronate catabolic process; IEA:Compara.
 GO:0006006; P:glucose metabolic process; TAS:ProtInc.
 GO:0019853; P:L-ascorbic acid biosynthetic process; IEA:Compara. 

Interpro

 IPR001395; Aldo/ket_red.
 IPR018170; Aldo/ket_reductase_CS.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 

Pfam

 PF00248; Aldo_ket_red 

SMART

  

PROSITE

 PS00798; ALDOKETO_REDUCTASE_1
 PS00062; ALDOKETO_REDUCTASE_2
 PS00063; ALDOKETO_REDUCTASE_3 

PRINTS

 PR00069; ALDKETRDTASE.