UniProt Accession

 MIOX_RAT; Q9QXN4; Q5S8C8; Q68G06; Q99PN7 

Genbank Protein ID

 AF197128; AF230096; AY738259; BC078840 

Genbank Nucleotide ID

 AAF25203.1; AAK00767.1; AAV65817.1; AAH78840.1 

Protein Name

 Inositol oxygenase 

Protein Synonyms/Alias

 Aldehyde reductase-like 6; Kidney-specific protein 32; Myo-inositol oxygenase; MI oxygenase; Renal-specific oxidoreductase 

Gene Name

 Miox 

Gene Synonyms/Alias

 Aldrl6; Ksp32; Rsor 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
2	******MKVDLGPDP	acetylation	[1]
23	DVDPEMAKSKGSFRN	acetylation	[1]
69	QFGSFSYKKMTVMEA	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

  

Sequence Annotation

 REGION 85 87 Substrate binding (By similarity).
 REGION 141 142 Substrate binding (By similarity).
 REGION 220 221 Substrate binding (By similarity).
 METAL 98 98 Iron 1 (By similarity).
 METAL 123 123 Iron 1 (By similarity).
 METAL 124 124 Iron 1 (By similarity).
 METAL 124 124 Iron 2 (By similarity).
 METAL 194 194 Iron 2 (By similarity).
 METAL 220 220 Iron 2 (By similarity).
 METAL 253 253 Iron 1 (By similarity).
 BINDING 29 29 Substrate (By similarity).
 BINDING 127 127 Substrate (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Iron; Metal-binding; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 285 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0016234; C:inclusion body; ISS:UniProtKB.
 GO:0004033; F:aldo-keto reductase (NADP) activity; ISS:UniProtKB.
 GO:0008199; F:ferric iron binding; ISS:UniProtKB.
 GO:0050113; F:inositol oxygenase activity; ISS:UniProtKB.
 GO:0050661; F:NADP binding; IDA:RGD.
 GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:Compara.
 GO:0019310; P:inositol catabolic process; ISS:UniProtKB. 

Interpro

 IPR018170; Aldo/ket_reductase_CS.
 IPR007828; Inositol_oxygenase. 

Pfam

 PF05153; DUF706 

SMART

  

PROSITE

 PS00063; ALDOKETO_REDUCTASE_3 

PRINTS