CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024337
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 NADPH-dependent diflavin oxidoreductase 1 
Protein Synonyms/Alias
  
Gene Name
 Ndor1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
329QHALEREKLLELSSAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Oxidoreductase that catalyzes the NADP-dependent reduction of cytochrome c and one-electron acceptors, such as doxorubicin, potassium ferricyanide and menadione (in vitro) (By similarity). 
Sequence Annotation
 DOMAIN 6 150 Flavodoxin-like.
 DOMAIN 206 448 FAD-binding FR-type.
 NP_BIND 12 16 FMN (By similarity).
 NP_BIND 94 125 FMN (By similarity).
 NP_BIND 242 253 FAD (By similarity).
 NP_BIND 379 389 FAD (By similarity).
 NP_BIND 455 473 NADP (By similarity).
 NP_BIND 544 560 NADP (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; FAD; Flavoprotein; FMN; NADP; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 598 AA 
Protein Sequence
MQVPQLLVLF GSQTGTAQDE AERLGREARR RRLGCRVQAL DSYSVANLIR EPLVIFVCAT 60
TGQGDPPDNM KNFWRFIFRK SLPSSSLCQM DFAVLGLGDS SYAKFNFVAK KLHRRLLQLG 120
GSALLPPCLG DDQHELGPDA AIDPWVGDLW EKIMVMYPVP LDIPEIPHGV PLPSKFIFQF 180
LQEVPSIGAE ELNIASSAPQ TPPSELQPFL APVITNQRVT GPQHFQDVRL IEFDITDSNI 240
SFAAGDVVFI LPSNSEAHTQ QFCQVLCLDP NQFFTLKPRE PGVPDPPGLP QPCTVWNLVS 300
QYLDIASVPR RSFFELLACL SQHALEREKL LELSSARGQE ELWEYCSRPR RTILEVLCDF 360
PHTAGAIPPD YLLDLIPRIR PRAFSIASSL LAHPRRLQIL VAVVKYQTRL KEPRHGLCSS 420
WLASLNPGQA GPVRVPLWVR PGSLVFPKTP DTPIIMVGAG TGVAPFRAAI QERVAHGQTG 480
NFLFFGCRQR DQDFYWQTEW QKLEQKGWLT LVTAFSREQE QKVYVQHRLR ELGPLVWELL 540
DGQGAYFYLA GNAKYLPTDV SEALMSIFQE EGRLSTADAS AYLARLQQTL RFQTETWA 598 
Gene Ontology
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0045111; C:intermediate filament cytoskeleton; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:Compara.
 GO:0010181; F:FMN binding; IEA:Compara.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0050661; F:NADP binding; IEA:Compara.
 GO:0003958; F:NADPH-hemoprotein reductase activity; IBA:RefGenome.
 GO:0016709; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; IBA:RefGenome.
 GO:0008219; P:cell death; ISS:UniProtKB.
 GO:0036245; P:cellular response to menadione; ISS:UniProtKB. 
Interpro
 IPR003097; FAD-binding_1.
 IPR017927; Fd_Rdtase_FAD-bd.
 IPR001094; Flavdoxin.
 IPR008254; Flavodoxin/NO_synth.
 IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
 IPR023173; NADPH_Cyt_P450_Rdtase_dom3.
 IPR001433; OxRdtase_FAD/NAD-bd.
 IPR017938; Riboflavin_synthase-like_b-brl. 
Pfam
 PF00667; FAD_binding_1
 PF00258; Flavodoxin_1
 PF00175; NAD_binding_1 
SMART
  
PROSITE
 PS51384; FAD_FR
 PS50902; FLAVODOXIN_LIKE 
PRINTS
 PR00369; FLAVODOXIN.
 PR00371; FPNCR.