CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007591
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leukemia inhibitory factor receptor 
Protein Synonyms/Alias
 LIF receptor; LIF-R; CD118 
Gene Name
 LIFR 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
804RIADLQGKTSYHLVLubiquitination[1]
866YRKREWIKETFYPDIubiquitination[2]
880IPNPENCKALQFQKSubiquitination[2]
886CKALQFQKSVCEGSSubiquitination[2]
896CEGSSALKTLEMNPCubiquitination[2]
Reference
 [1] Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
 Xu G, Paige JS, Jaffrey SR.
 Nat Biotechnol. 2010 Aug;28(8):868-73. [PMID: 20639865]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells. 
Sequence Annotation
 DOMAIN 46 131 Fibronectin type-III 1.
 DOMAIN 332 428 Fibronectin type-III 2.
 DOMAIN 433 530 Fibronectin type-III 3.
 DOMAIN 535 625 Fibronectin type-III 4.
 DOMAIN 627 719 Fibronectin type-III 5.
 DOMAIN 724 829 Fibronectin type-III 6.
 MOTIF 519 523 WSXWS motif.
 MOTIF 869 877 Box 1 motif.
 MOD_RES 927 927 Phosphoserine.
 CARBOHYD 64 64 N-linked (GlcNAc...) (Potential).
 CARBOHYD 85 85 N-linked (GlcNAc...) (Potential).
 CARBOHYD 131 131 N-linked (GlcNAc...).
 CARBOHYD 143 143 N-linked (GlcNAc...) (Potential).
 CARBOHYD 191 191 N-linked (GlcNAc...) (Potential).
 CARBOHYD 243 243 N-linked (GlcNAc...) (Potential).
 CARBOHYD 303 303 N-linked (GlcNAc...).
 CARBOHYD 390 390 N-linked (GlcNAc...) (Potential).
 CARBOHYD 407 407 N-linked (GlcNAc...).
 CARBOHYD 426 426 N-linked (GlcNAc...).
 CARBOHYD 445 445 N-linked (GlcNAc...) (Potential).
 CARBOHYD 481 481 N-linked (GlcNAc...) (Potential).
 CARBOHYD 489 489 N-linked (GlcNAc...) (Potential).
 CARBOHYD 572 572 N-linked (GlcNAc...) (Potential).
 CARBOHYD 652 652 N-linked (GlcNAc...) (Potential).
 CARBOHYD 663 663 N-linked (GlcNAc...) (Potential).
 CARBOHYD 680 680 N-linked (GlcNAc...) (Potential).
 CARBOHYD 729 729 N-linked (GlcNAc...) (Potential).
 CARBOHYD 787 787 N-linked (GlcNAc...) (Potential).
 DISULFID 55 65
 DISULFID 82 90
 DISULFID 213 270
 DISULFID 341 351
 DISULFID 466 511  
Keyword
 3D-structure; Alternative splicing; Cell membrane; Chromosomal rearrangement; Complete proteome; Disease mutation; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1097 AA 
Protein Sequence
MMDIYVCLKR PSWMVDNKRM RTASNFQWLL STFILLYLMN QVNSQKKGAP HDLKCVTNNL 60
QVWNCSWKAP SGTGRGTDYE VCIENRSRSC YQLEKTSIKI PALSHGDYEI TINSLHDFGS 120
STSKFTLNEQ NVSLIPDTPE ILNLSADFST STLYLKWNDR GSVFPHRSNV IWEIKVLRKE 180
SMELVKLVTH NTTLNGKDTL HHWSWASDMP LECAIHFVEI RCYIDNLHFS GLEEWSDWSP 240
VKNISWIPDS QTKVFPQDKV ILVGSDITFC CVSQEKVLSA LIGHTNCPLI HLDGENVAIK 300
IRNISVSASS GTNVVFTTED NIFGTVIFAG YPPDTPQQLN CETHDLKEII CSWNPGRVTA 360
LVGPRATSYT LVESFSGKYV RLKRAEAPTN ESYQLLFQML PNQEIYNFTL NAHNPLGRSQ 420
STILVNITEK VYPHTPTSFK VKDINSTAVK LSWHLPGNFA KINFLCEIEI KKSNSVQEQR 480
NVTIKGVENS SYLVALDKLN PYTLYTFRIR CSTETFWKWS KWSNKKQHLT TEASPSKGPD 540
TWREWSSDGK NLIIYWKPLP INEANGKILS YNVSCSSDEE TQSLSEIPDP QHKAEIRLDK 600
NDYIISVVAK NSVGSSPPSK IASMEIPNDD LKIEQVVGMG KGILLTWHYD PNMTCDYVIK 660
WCNSSRSEPC LMDWRKVPSN STETVIESDE FRPGIRYNFF LYGCRNQGYQ LLRSMIGYIE 720
ELAPIVAPNF TVEDTSADSI LVKWEDIPVE ELRGFLRGYL FYFGKGERDT SKMRVLESGR 780
SDIKVKNITD ISQKTLRIAD LQGKTSYHLV LRAYTDGGVG PEKSMYVVTK ENSVGLIIAI 840
LIPVAVAVIV GVVTSILCYR KREWIKETFY PDIPNPENCK ALQFQKSVCE GSSALKTLEM 900
NPCTPNNVEV LETRSAFPKI EDTEIISPVA ERPEDRSDAE PENHVVVSYC PPIIEEEIPN 960
PAADEAGGTA QVIYIDVQSM YQPQAKPEEE QENDPVGGAG YKPQMHLPIN STVEDIAAEE 1020
DLDKTAGYRP QANVNTWNLV SPDSPRSIDS NSEIVSFGSP CSINSRQFLI PPKDEDSPKS 1080
NGGGWSFTNF FQNKPND 1097 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0004923; F:leukemia inhibitory factor receptor activity; IDA:MGI.
 GO:0038165; P:oncostatin-M-mediated signaling pathway; IDA:GOC.
 GO:0008284; P:positive regulation of cell proliferation; IDA:BHF-UCL. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR003529; Hematopoietin_rcpt_Gp130_CS.
 IPR013783; Ig-like_fold. 
Pfam
 PF00041; fn3 
SMART
 SM00060; FN3 
PROSITE
 PS50853; FN3
 PS01353; HEMATOPO_REC_L_F2 
PRINTS