UniProt Accession

 B4DTM7_HUMAN; B4DTM7 

Genbank Protein ID

 AL596247; AL731576; AK300280 

Genbank Nucleotide ID

 BAG62039.1 

Protein Name

 Uncharacterized protein 

Protein Synonyms/Alias

 Vinculin; cDNA FLJ53006, highly similar to Vinculin 

Gene Name

 VCL 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
176	EARKWSSKGNDIIAA	ubiquitination	[1]
257	PTISTQLKILSTVKA	ubiquitination	[2]
263	LKILSTVKATMLGRT	ubiquitination	[2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 327 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IEA:InterPro.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0007155; P:cell adhesion; IEA:InterPro. 

Interpro

 IPR017997; Vinculin.
 IPR006077; Vinculin/catenin. 

Pfam

 PF01044; Vinculin 

SMART

  

PROSITE

  

PRINTS

 PR00806; VINCULIN.