UniProt Accession

 GBRB2_MOUSE; P63137; A6H6R7; D1LYT3; P15432 

Genbank Protein ID

 U14419; GU086167; AK090279; AL627444; AL645964; AL645964; AL627444; CH466609; BC145973; BC145975 

Genbank Nucleotide ID

 AAA79974.1; ACY69098.1; BAC41155.1; CAI25055.1; CAI25055.1; CAI25222.1; CAI25222.1; EDL32344.1; AAI45974.1; AAI45976.1 

Protein Name

 Gamma-aminobutyric acid receptor subunit beta-2 

Protein Synonyms/Alias

 GABA(A) receptor subunit beta-2 

Gene Name

 Gabrb2 

Gene Synonyms/Alias

 Gabrb-2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
45	ETVDRLLKGYDIRLR	ubiquitination	[1]
126	DTYFLNDKKSFVHGV	ubiquitination	[1]
359	KMRLDVNKMDPHENI	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. 

Sequence Annotation

 MOD_RES 434 434 Phosphotyrosine.
 MOD_RES 441 441 Phosphotyrosine.
 CARBOHYD 32 32 N-linked (GlcNAc...) (Potential).
 CARBOHYD 104 104 N-linked (GlcNAc...) (Potential).
 CARBOHYD 173 173 N-linked (GlcNAc...) (Potential).
 DISULFID 160 174 By similarity.
 CROSSLNK 45 45 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Alternative splicing; Cell junction; Cell membrane; Chloride; Chloride channel; Complete proteome; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Isopeptide bond; Ligand-gated ion channel; Membrane; Phosphoprotein; Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix; Transport; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 512 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
 GO:0004890; F:GABA-A receptor activity; IEA:InterPro.
 GO:0005237; F:inhibitory extracellular ligand-gated ion channel activity; IEA:Compara.
 GO:0090102; P:cochlea development; IMP:DFLAT.
 GO:0060119; P:inner ear receptor cell development; IMP:DFLAT.
 GO:0060384; P:innervation; IMP:DFLAT.
 GO:0043524; P:negative regulation of neuron apoptotic process; IMP:DFLAT.
 GO:0007605; P:sensory perception of sound; IMP:DFLAT.
 GO:0051932; P:synaptic transmission, GABAergic; IEA:Compara. 

Interpro

 IPR006028; GABAA_rcpt.
 IPR002289; GABAAb_rcpt.
 IPR006202; Neur_chan_lig-bd.
 IPR006201; Neur_channel.
 IPR006029; Neurotrans-gated_channel_TM.
 IPR018000; Neurotransmitter_ion_chnl_CS. 

Pfam

 PF02931; Neur_chan_LBD
 PF02932; Neur_chan_memb 

SMART

  

PROSITE

 PS00236; NEUROTR_ION_CHANNEL 

PRINTS

 PR01160; GABAARBETA.
 PR00253; GABAARECEPTR.
 PR00252; NRIONCHANNEL.