CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034008
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Filamin-C 
Protein Synonyms/Alias
  
Gene Name
 Flnc 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
81LLEVLSQKRMYRKFHacetylation[1]
114FLEREHIKLVSIDSKacetylation[1, 2]
499VKEVADFKVFTKGAGacetylation[2]
503ADFKVFTKGAGSGELacetylation[1]
574SPEAGAQKVRAWGPGacetylation[3]
574SPEAGAQKVRAWGPGsuccinylation[3]
735RCSYVPTKPIKHTIIacetylation[2, 3, 4]
777VYGPGVEKTGLKANEacetylation[2]
777VYGPGVEKTGLKANEubiquitination[5]
872SHDASKVKAEGPGLSubiquitination[5]
887RTGVEVGKPTHFTVLacetylation[3]
969APPLDLSKVKVQGLNacetylation[2]
1015SRRPIPCKLEPGGGAacetylation[1, 2]
1015SRRPIPCKLEPGGGAubiquitination[5]
1300VLNPSGAKTDTYVTDubiquitination[5]
1368LEGGLVNKANRFTVEubiquitination[5]
1531EVPRSPFKIKVLPSHubiquitination[5]
1533PRSPFKIKVLPSHDAubiquitination[5]
1799VRYAPTEKGLHQMGIacetylation[2]
1903IIVRFDDKHIPGSPFacetylation[1, 2]
1903IIVRFDDKHIPGSPFubiquitination[5]
1962NEEPCLLKRLPNRHIacetylation[1]
1962NEEPCLLKRLPNRHIubiquitination[5]
1990VSVRKSGKHVTNSPFacetylation[3]
1998HVTNSPFKILVGPSEacetylation[2]
2259GPHTVTVKYRGQHVPubiquitination[5]
2664PCEEVYVKHMGNRVYacetylation[1]
2678YNVTYTVKEKGDYILacetylation[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [5] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2704 AA 
Protein Sequence
MMNNSNYSDA SGLGLVDEAD EMPSTEKDLA EDAPWKKIQQ NTFTRWCNEH LKCVGKRLTD 60
LQRDLSDGLR LIALLEVLSQ KRMYRKFHPR PNFRQMKLEN VSVALEFLER EHIKLVSIDS 120
KAIVDGNLKL ILGLIWTLIL HYSISMPMWE DEDDEDARKQ TPKQRLLGWI QNKVPQLPIT 180
NFNRDWQDGK ALGALVDNCA PGLCPDWEAW DPNQPVQNAR EAMQQADDWL GVPQVIAPEE 240
IVDPNVDEHS VMTYLSQFPK AKLKPGAPVR SKQLNPKKAI AYGPGIEPQG NTVLQPAHFT 300
VQTVDAGVGE VLVYIEDPEG HTEEAKVVPN NDKDRTYAVS YVPKVAGLHK VTVLFAGQNI 360
ERSPFEVNVG MALGDANKVS ARGPGLEPVG NVANKPTYFD IYTAGAGTGD VAVVIVDPQG 420
RRDTVEVALE DKGDNTFRCT YRPVMEGPHT VHVAFAGAPI TRSPFPVHVA EACNPNACRA 480
SGRGLQPKGV RVKEVADFKV FTKGAGSGEL KVTVKGPKGT EEPVKVREAG DGVFECEYYP 540
VVPGKYVVTI TWGGYAIPRS PFEVQVSPEA GAQKVRAWGP GLETGQVGKS ADFVVEAIGT 600
EVGTLGFSIE GPSQAKIECD DKGDGSCDVR YWPTEPGEYA VHVICDDEDI RDSPFIAHIQ 660
PAPPDCFPDK VKAFGPGLEP TGCIVDRPAE FTIDARAAGK GDLKLYAQDA DGCPIDIKVI 720
PNGDGTFRCS YVPTKPIKHT IIVSWGGVNV PKSPFRVNVG EGSHPERVKV YGPGVEKTGL 780
KANEPTYFTV DCSEAGQGDV SIGIKCAPGV VGPVEADIDF DIIKNDNDTF TVKYTPPGAG 840
HYTIMVLFAN QEIPASPFHI KVDPSHDASK VKAEGPGLSR TGVEVGKPTH FTVLTKGAGK 900
AKLDVHFAGA AKGEAVRDFE IIDNHDYSYT VKYTAVQQGN MAVTVTYGGD PVPKSPFVVN 960
VAPPLDLSKV KVQGLNSKVA VGQEQAFSVN TRGAGGQGQL DVRMTSPSRR PIPCKLEPGG 1020
GAEAQAVRYM PPEEGPYKVD ITYDGHPVPG SPFAVEGVLP PDPSKVCAYG PGLKGGLVGT 1080
PAPFSIDTKG AGTGGLGLTV EGPCEAKIEC QDNGDGSCAV SYLPTEPGEY TINILFAEAH 1140
IPGSPFKATI QPVFDPSKVR ASGPGLERGK AGEAATFTVD CSEAGEAELT IEILSDAGVK 1200
AEVLIQNNAD GTYHITYSPA FPGTYTITIK YGGHPIPKFP TRVHVQPAVD TSGIKVSGPG 1260
VEPHGVLREV TTEFTVDARS LTATGGNHVT ARVLNPSGAK TDTYVTDNGD GTYRVQYTAY 1320
EEGVHLVEVL YDEVAVPKSP FRVGVTEGCD PTRVRAFGPG LEGGLVNKAN RFTVETRGAG 1380
TGGLGLAIEG PSEAKMSCKD NKDGSCTVEY IPFTPGDYDV NITFGGQPIP GSPFRVPVKD 1440
VVDPGKVKCS GPGLGTGVRA RVPQTFTVDC SQAGRAPLQV AVLGPTGVAE PVEVRDNGDG 1500
THTVHYTPAT DGPYTVAVKY ADQEVPRSPF KIKVLPSHDA SKVRASGPGL NASGIPASLP 1560
VEFTIDARDA GQGLLTVQIL DPEGKPKKAN IRDNGDGTYT VSYLPDMSGR YTITIKYGGD 1620
EIPYSPFRIH ALPTGDASKC LVTVSIGGHG LGACLGPRIQ IGEETVITVD AKAAGKGKVT 1680
CTVSTPDGAE LDVDVVENHD GTFDIYYTAP EPGKYVITIR FGGEHIPNSP FHVLATEEPV 1740
VPVEPLESML RPFNLVIPFT VQKGELTGEV RMPSGKTARP NITDNKDGTI TVRYAPTEKG 1800
LHQMGIKYDG NHIPGSPLQF YVDAINSRHV SAYGPGLSHG MVNKPATFTI VTKDAGEGGL 1860
SLAVEGPSKA EITCKDNKDG TCTVSYLPTA PGDYSIIVRF DDKHIPGSPF TAKITGDDSM 1920
RTSQLNVGTS TDVSLKITEG DLSQLTASIR APSGNEEPCL LKRLPNRHIG ISFTPKEVGE 1980
HVVSVRKSGK HVTNSPFKIL VGPSEIGDAS KVRVWGKGLS EGQTFQVAEF IVDTRNAGYG 2040
GLGLSIEGPS KVDINCEDME DGTCKVTYCP TEPGTYIINI KFADKHVPGS PFTVKVTGEG 2100
RMKESITRRR QAPSIATIGS TCDLNLKIPG NWFQMVSAQE RLTRTFTRSS HTYTRTERTE 2160
ISKTRGGETK REVRVEESTQ VGGDPFPAVF GDFLGRERLG SFGSITRQQE GEASSQDMTA 2220
QVTSPSGKTE AAEIVEGEDS AYSVRFVPQE MGPHTVTVKY RGQHVPGSPF QFTVGPLGEG 2280
GAHKVRAGGT GLERGVAGVP AEFSIWTREA GAGGLSIAVE GPSKAEIAFE DRKDGSCGVS 2340
YVVQEPGDYE VSIKFNDEHI PDSPFVVPVA SLSDDARRLT VTSLQETGLK VNQPASFAVQ 2400
LNGARGVIDA RVHTPSGAVE ECYVSELDSD KHTIRFIPHE NGVHSIDVKF NGAHIPGSPF 2460
KIRVGEQSQA GDPGLVSAYG PGLEGGTTGV SSEFIVNTQN AGSGALSVTI DGPSKVQLDC 2520
RECPEGHVVT YTPMAPGNYL IAIKYGGPQH IVGSPFKAKV TGPRLSGGHS LHETSTVLVE 2580
TVTKSSSSRG ASYSSIPKFS SDASKVVTRG PGLSQAFVGQ KNSFTVDCSK AGMFHPRGLS 2640
WGGTNMMMVG VHGPKTPCEE VYVKHMGNRV YNVTYTVKEK GDYILIVKWG DESVPGSPFK 2700
VNVP 2704 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; TAS:MGI.
 GO:0003779; F:actin binding; TAS:MGI.
 GO:0030029; P:actin filament-based process; TAS:MGI. 
Interpro
 IPR001589; Actinin_actin-bd_CS.
 IPR001715; CH-domain.
 IPR003961; Fibronectin_type3.
 IPR001298; Filamin.
 IPR017868; Filamin/ABP280_repeat-like.
 IPR013783; Ig-like_fold.
 IPR014756; Ig_E-set. 
Pfam
 PF00307; CH
 PF00630; Filamin 
SMART
 SM00033; CH
 SM00060; FN3
 SM00557; IG_FLMN 
PROSITE
 PS00019; ACTININ_1
 PS00020; ACTININ_2
 PS50021; CH
 PS50194; FILAMIN_REPEAT 
PRINTS