CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005260
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium-dependent noradrenaline transporter 
Protein Synonyms/Alias
 Norepinephrine transporter; NET; Solute carrier family 6 member 2 
Gene Name
 SLC6A2 
Gene Synonyms/Alias
 NAT1; NET1; SLC6A5 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
29EQPLRARKTAELLVVubiquitination[1]
37TAELLVVKERNGVQCubiquitination[1]
204GNHTKYSKYKFTPAAubiquitination[1]
206HTKYSKYKFTPAAEFubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals. 
Sequence Annotation
 CARBOHYD 184 184 N-linked (GlcNAc...) (Potential).
 CARBOHYD 192 192 N-linked (GlcNAc...) (Potential).
 CARBOHYD 198 198 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Disease mutation; Glycoprotein; Membrane; Neurotransmitter transport; Polymorphism; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 617 AA 
Protein Sequence
MLLARMNPQV QPENNGADTG PEQPLRARKT AELLVVKERN GVQCLLAPRD GDAQPRETWG 60
KKIDFLLSVV GFAVDLANVW RFPYLCYKNG GGAFLIPYTL FLIIAGMPLF YMELALGQYN 120
REGAATVWKI CPFFKGVGYA VILIALYVGF YYNVIIAWSL YYLFSSFTLN LPWTDCGHTW 180
NSPNCTDPKL LNGSVLGNHT KYSKYKFTPA AEFYERGVLH LHESSGIHDI GLPQWQLLLC 240
LMVVVIVLYF SLWKGVKTSG KVVWITATLP YFVLFVLLVH GVTLPGASNG INAYLHIDFY 300
RLKEATVWID AATQIFFSLG AGFGVLIAFA SYNKFDNNCY RDALLTSSIN CITSFVSGFA 360
IFSILGYMAH EHKVNIEDVA TEGAGLVFIL YPEAISTLSG STFWAVVFFV MLLALGLDSS 420
MGGMEAVITG LADDFQVLKR HRKLFTFGVT FSTFLLALFC ITKGGIYVLT LLDTFAAGTS 480
ILFAVLMEAI GVSWFYGVDR FSNDIQQMMG FRPGLYWRLC WKFVSPAFLL FVVVVSIINF 540
KPLTYDDYIF PPWANWVGWG IALSSMVLVP IYVIYKFLST QGSLWERLAY GITPENEHHL 600
VAQRDIRQFQ LQHWLAI 617 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005334; F:norepinephrine:sodium symporter activity; TAS:ProtInc.
 GO:0048265; P:response to pain; IEA:Compara.
 GO:0007268; P:synaptic transmission; TAS:ProtInc. 
Interpro
 IPR000175; Na/ntran_symport.
 IPR002435; Na/ntran_symport_noradrenaline. 
Pfam
 PF00209; SNF 
SMART
  
PROSITE
 PS00610; NA_NEUROTRAN_SYMP_1
 PS00754; NA_NEUROTRAN_SYMP_2
 PS50267; NA_NEUROTRAN_SYMP_3 
PRINTS
 PR00176; NANEUSMPORT.
 PR01201; NORTRANSPORT.