Tag | Content |
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CPLM ID | CPLM-000859 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Desmoglein-2 |
Protein Synonyms/Alias | |
Gene Name | Dsg2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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698 | GVGGAMLKEGMMKGS | ubiquitination | [1] | 712 | SSSASVTKGQHELSE | ubiquitination | [1] | 783 | LRSYFTEKAASYNGE | ubiquitination | [1] | 987 | QHYANEEKVLVTERV | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. |
Sequence Annotation | DOMAIN 55 164 Cadherin 1. DOMAIN 165 277 Cadherin 2. DOMAIN 278 398 Cadherin 3. DOMAIN 397 504 Cadherin 4. REPEAT 885 916 Desmoglein repeat 1. REPEAT 917 945 Desmoglein repeat 2. REPEAT 946 971 Desmoglein repeat 3. REPEAT 972 995 Desmoglein repeat 4. REPEAT 996 1024 Desmoglein repeat 5. REPEAT 1025 1055 Desmoglein repeat 6. MOD_RES 685 685 Phosphoserine (By similarity). MOD_RES 709 709 Phosphoserine (By similarity). CARBOHYD 117 117 N-linked (GlcNAc...) (Potential). CARBOHYD 314 314 N-linked (GlcNAc...) (Potential). CARBOHYD 467 467 N-linked (GlcNAc...). CARBOHYD 519 519 N-linked (GlcNAc...) (Potential). |
Keyword | Calcium; Cell adhesion; Cell junction; Cell membrane; Cleavage on pair of basic residues; Complete proteome; Glycoprotein; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1122 AA |
Protein Sequence | MARSPGDRCA LLLLVQLLAV VCLDFGNGLH LEVFSPRNEG KPFPKHTHLV RQKRAWITAP 60 VALREGEDLS RKNPIAKIHS DLAEEKGIKI TYKYTGKGIT EPPFGIFVFD RNTGELNITS 120 ILDREETPYF LLTGYALDSR GNNLEKPLEL RIKVLDINDN EPVFTQEVFV GSIEELSAAH 180 TLVMKITATD ADDPETLNAK VSYRIVSQEP ANSHMFYLNK DTGEIYTTSF TLDREEHSSY 240 SLTVEARDGN GQITDKPVQQ AQVQIRILDV NDNIPVVENK MYEGTVEENQ VNVEVMRIKV 300 TDADEVGSDN WLANFTFASG NEGGYFHIET DTQTNEGIVT LVKEVDYEEM KKLDLSIIVT 360 NKAAFHKSIL SKYKATPIPI TVKVKNVVEG IHFKSSVVSF RASEAMDRSS LSRSIGNFQV 420 FDEDTGQAAK VTYVKVQDTD NWVSVDSVTS EIKLVKIPDF ESRYVQNGTY TAKVVAISKE 480 HPQKTITGTI VITVEDVNDN CPVLVDSVRS VCEDEPYVNV TAEDLDGAQN SAPFSFSIID 540 QPPGTAQKWK ITHQESTSVL LQQSERKRGR SEIPFLISDS QGFSCPERQV LQLTVCECLK 600 GGGCVAAQYD NYVGLGPAAI ALMILALLLL LLVPLLLLIC HCGGGAKGFT PIPGTIEMLH 660 PWNNEGAPPE DKVVPSLLVA DHAESSAVRG GVGGAMLKEG MMKGSSSASV TKGQHELSEV 720 DGRWEEHRSL LTAGATHHVR TAGTIAANEA VRTRATGSSR DMSGARGAVA VNEEFLRSYF 780 TEKAASYNGE DDLHMAKDCL LVYSQEDTAS LRGSVGCCSF IEGELDDLFL DDLGLKFKTL 840 AEVCLGRKID LDVDIEQRQK PVREASVSAA SGSHYEQAVT SSESAYSSNT GFPAPKPLHE 900 VHTEKVTQEI VTESSVSSRQ SQKVVPPPDP VASGNIIVTE TSYAKGSAVP PSTVLLAPRQ 960 PQSLIVTERV YAPTSTLVDQ HYANEEKVLV TERVIQPNGG IPKPLEVTQH LKDAQYVMVR 1020 ERESILAPSS GVQPTLAMPS VAAGGQNVTV TERILTPAST LQSSYQIPSE TSITARNTVL 1080 SSVGSIGPLP NLDLEESDRP NSTITTSSTR VTKHSTMQHS YS 1122 |
Gene Ontology | GO:0030057; C:desmosome; IDA:MGI. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0086069; P:bundle of His cell to Purkinje myocyte communication; IEA:Compara. GO:0097194; P:execution phase of apoptosis; IEA:Compara. GO:0007156; P:homophilic cell adhesion; IEA:InterPro. GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Compara. GO:0086005; P:regulation of ventricular cardiac muscle cell action potential; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |