| Tag | Content |
|---|
| CPLM ID | CPLM-019302 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 4-hydroxybenzoate polyprenyltransferase, mitochondrial |
Protein Synonyms/Alias | COQ2 homolog; hCOQ2; Para-hydroxybenzoate--polyprenyltransferase; PHB:polyprenyltransferase |
Gene Name | COQ2 |
Gene Synonyms/Alias | CL640 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 265 | DDVLIGLKSTALRFG | ubiquitination | [1] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] |
Functional Description | Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB. |
Sequence Annotation | |
Keyword | Alternative splicing; Complete proteome; Disease mutation; Isoprene biosynthesis; Membrane; Mitochondrion; Reference proteome; Transferase; Transit peptide; Transmembrane; Transmembrane helix; Ubiquinone biosynthesis. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 371 AA |
Protein Sequence | MLGSRAAGFA RGLRALALAW LPGWRGRSFA LARAAGAPHG GDLQPPACPE PRGRQLSLSA 60
AAVVDSAPRP LQPYLRLMRL DKPIGTWLLY LPCTWSIGLA AEPGCFPDWY MLSLFGTGAI 120
LMRGAGCTIN DMWDQDYDKK VTRTANRPIA AGDISTFQSF VFLGGQLTLA LGVLLCLNYY 180
SIALGAGSLL LVITYPLMKR ISYWPQLALG LTFNWGALLG WSAIKGSCDP SVCLPLYFSG 240
VMWTLIYDTI YAHQDKRDDV LIGLKSTALR FGENTKPWLS GFSVAMLGAL SLVGVNSGQT 300
APYYAALGAV GAHLTHQIYT LDIHRPEDCW NKFISNRTLG LIVFLGIVLG NLWKEKKTDK 360
TKKGIENKIE N 371 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005743; C:mitochondrial inner membrane; TAS:Reactome. GO:0002083; F:4-hydroxybenzoate decaprenyltransferase activity; IEA:EC. GO:0047293; F:4-hydroxybenzoate nonaprenyltransferase activity; IEA:EC. GO:0006071; P:glycerol metabolic process; IGI:UniProtKB. GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW. GO:0006744; P:ubiquinone biosynthetic process; IDA:UniProtKB. |
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