UniProt Accession

 DCE1_MOUSE; P48318; O08685 

Genbank Protein ID

 Z49976; Y12257; AF483492; AF483493; BC027059; S67453 

Genbank Nucleotide ID

 CAA90277.1; CAA72934.1; AAL90766.1; AAL90767.1; AAH27059.1 

Protein Name

 Glutamate decarboxylase 1 

Protein Synonyms/Alias

 67 kDa glutamic acid decarboxylase; GAD-67; Glutamate decarboxylase 67 kDa isoform 

Gene Name

 Gad1 

Gene Synonyms/Alias

 Gad67 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
470	FWLMWKAKGTVGFEN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes the production of GABA. 

Sequence Annotation

 REGION 189 191 Substrate binding (By similarity).
 BINDING 566 566 Substrate (By similarity).
 MOD_RES 404 404 N6-(pyridoxal phosphate)lysine (By  

Keyword

 Complete proteome; Decarboxylase; Lyase; Neurotransmitter biosynthesis; Pyridoxal phosphate; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 593 AA 

Protein Sequence

Gene Ontology

 GO:0043679; C:axon terminus; IDA:MGI.
 GO:0005938; C:cell cortex; IDA:MGI.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0048786; C:presynaptic active zone; IDA:MGI.
 GO:0004351; F:glutamate decarboxylase activity; IEA:EC.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0006915; P:apoptotic process; IMP:MGI.
 GO:0048854; P:brain morphogenesis; IMP:MGI.
 GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
 GO:0021696; P:cerebellar cortex morphogenesis; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0035108; P:limb morphogenesis; IMP:MGI.
 GO:0035264; P:multicellular organism growth; IMP:MGI.
 GO:0061351; P:neural precursor cell proliferation; IMP:MGI.
 GO:0001764; P:neuron migration; IMP:MGI.
 GO:0042136; P:neurotransmitter biosynthetic process; IEA:UniProtKB-KW.
 GO:0021772; P:olfactory bulb development; IMP:MGI. 

Interpro

 IPR002129; PyrdxlP-dep_de-COase.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2.
 IPR021115; Pyridoxal-P_BS. 

Pfam

 PF00282; Pyridoxal_deC 

SMART

  

PROSITE

 PS00392; DDC_GAD_HDC_YDC 

PRINTS