CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018572
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sorting nexin-4 
Protein Synonyms/Alias
  
Gene Name
 Snx4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
175HPVLCRDKIFYSFLTacetylation[1]
175HPVLCRDKIFYSFLTubiquitination[2]
376EQREARIKVLEEQINubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation (By similarity). 
Sequence Annotation
 DOMAIN 61 187 PX.
 BINDING 106 106 Phosphatidylinositol 3-phosphate (By
 BINDING 108 108 Phosphatidylinositol 3-phosphate; via
 BINDING 132 132 Phosphatidylinositol 3-phosphate (By
 BINDING 154 154 Phosphatidylinositol 3-phosphate (By
 MOD_RES 1 1 N-acetylmethionine (By similarity).  
Keyword
 Acetylation; Complete proteome; Endosome; Lipid-binding; Membrane; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 450 AA 
Protein Sequence
MEQAPPDPEK LLQPGPLEPL GGPGAVLEAA VGEENEGTRE DGSGVDTMTG NNFWLKKIEI 60
SVSEAEKRTG RNAVNMQETY TAYLIETRSV EHADGQSVLT DSLWRRYSEF ELLRNYLLVY 120
YPHVVVPPLP EKRAEFVWHK LSADNMDPDF VERRRVGLEN FLLRVASHPV LCRDKIFYSF 180
LTQEGNWKET VNETGFQLKA DSRLKALNAT FRVKNPDKRF TELRHYSDEL QSVISHLLRV 240
RARVADRLYG VYKVHGNYGR VFSEWSAIEK EMGDGLQSAG HHMDVYASSI DDILEDEEHY 300
ADQLKEYLFY AEALRAVCRK HELMQYDLET AAQDLAAKKQ QCEELATGTV RTFSLKGMTT 360
KLFGQETPEQ REARIKVLEE QINEGEQQLK SKNLEGREFV KNAWADIERF KEQKNRDLKE 420
ALISYAVMQI SMCKKGIQVW TNAKECFSKM 450 
Gene Ontology
 GO:0005868; C:cytoplasmic dynein complex; ISS:UniProtKB.
 GO:0031901; C:early endosome membrane; ISS:UniProtKB.
 GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0032456; P:endocytic recycling; ISS:UniProtKB.
 GO:0015031; P:protein transport; ISS:UniProtKB. 
Interpro
 IPR001683; Phox. 
Pfam
 PF00787; PX 
SMART
 SM00312; PX 
PROSITE
 PS50195; PX 
PRINTS