CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039878
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Rab GTPase-binding effector protein 1 
Protein Synonyms/Alias
  
Gene Name
 RABEP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
56ATVSENTKQEAIDEVubiquitination[1]
64QEAIDEVKRQWREEVubiquitination[1, 2, 3]
477TEWNLLQKEVHNAGNubiquitination[4]
543QELEDFIKQSSEDSSubiquitination[3]
604EELVRLQKDNDSLQGubiquitination[2]
809RAILNDTKLTDINQLubiquitination[2]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 819 AA 
Protein Sequence
MAQPGPASQP DEDLKRQNAV LQAAQDDLGH LRTQLWEAQA EMENIKAIAT VSENTKQEAI 60
DEVKRQWREE VASLQAVMKE TVRDYEHQFH LRLEQERTQW AQYRESAERE IADLRRRLSE 120
GQEEENLENE MKKAQEDAEK LRSVVMPMEK EIAALKDKLT EAEDKIKELE ASKVKELNHY 180
LEAEKSCRTD LEMYVAVLNT QKSVLQEDAE KLRKELHEVC HLLEQERQQH NQLKHTWQKA 240
NDQFLESQRL LMRDMQRMEI VLTSEQLRQV EELKKKDQED DEQQRLNKRK DHKKADVEEE 300
IKIPVVCALT QEESSAQLSN EEEHLDSTRG SVHSLDAGLL LPSGDPFSKS DNDMFKDGLR 360
RAQSTDSLGT SGSLQSKALG YNYKAKSAGN LDESDFGPLV GADSVSENFD TASLGSLQMP 420
SGFMLTKDQE RAIKAMTPEQ EETASLLSSV TQGMESAYVS PSGYRLVSET EWNLLQKEVH 480
NAGNKLGRRC DMCSNYEKQL QGIQIQEAET RDQVKKLQLM LRQANDQLEK TMKDKQELED 540
FIKQSSEDSS HQISALVLRA QASEILLEEL QQGLSQAKRD VQEQMAVLMQ SREQVSEELV 600
RLQKDNDSLQ GKHSLHVSLQ QAEDFILPDT TEALRELVLK YREDIINVRT AADHVEEKLK 660
AEILFLKEQI QAEQCLKENL EETLQLEIEN CKEEIASISS LKAELERIKV EKGQLESTLR 720
EKSQQLESLQ EIKISLEEQL KKETAAKATV EQLMFEEKNK AQRLQTELDV SEQVQRDFVK 780
LSQTLQVQLE RIRQADSLER IRAILNDTKL TDINQLPET 819 
Gene Ontology
 GO:0005096; F:GTPase activator activity; IEA:InterPro.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC. 
Interpro
 IPR003914; Rabaptin.
 IPR018514; Rabaptin_coiled-coil.
 IPR015390; Rabaptin_Rab5-bd_dom. 
Pfam
 PF09311; Rab5-bind
 PF03528; Rabaptin 
SMART
  
PROSITE
  
PRINTS
 PR01432; RABAPTIN.