UniProt Accession

 UPP_ECOLI; P0A8F0; P25532; P78095; Q8XAC7 

Genbank Protein ID

 X57104; U00096; AP009048 

Genbank Nucleotide ID

 CAA40388.1; AAC75551.2; BAA16386.1 

Protein Name

 Uracil phosphoribosyltransferase 

Protein Synonyms/Alias

 UMP pyrophosphorylase; UPRTase 

Gene Name

 upp 

Gene Synonyms/Alias

 uraP; b2498; JW2483 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
2	******MKIVEVKHP	acetylation	[1]
7	*MKIVEVKHPLVKHK	acetylation	[1]
67	PVEIDQIKGKKITVV	acetylation	[1]
69	EIDQIKGKKITVVPI	acetylation	[1]
70	IDQIKGKKITVVPIL	acetylation	[1]
116	EPVPYFQKLVSNIDE	acetylation	[1]
203	GLGDAGDKIFGTK**	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. 

Sequence Annotation

 REGION 130 138 5-phospho-alpha-D-ribose 1-diphosphate
 REGION 198 200 Uracil binding (By similarity).
 BINDING 78 78 5-phospho-alpha-D-ribose 1-diphosphate
 BINDING 103 103 5-phospho-alpha-D-ribose 1-diphosphate
 BINDING 193 193 Uracil; via amide nitrogen (By
 BINDING 199 199 5-phospho-alpha-D-ribose 1-diphosphate  

Keyword

 3D-structure; Allosteric enzyme; Complete proteome; Direct protein sequencing; Glycosyltransferase; GTP-binding; Magnesium; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 208 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0016020; C:membrane; IDA:UniProtKB.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0000287; F:magnesium ion binding; IEA:HAMAP.
 GO:0004845; F:uracil phosphoribosyltransferase activity; IEA:HAMAP.
 GO:0044206; P:UMP salvage; IEA:UniProtKB-UniPathway.
 GO:0006223; P:uracil salvage; IEA:InterPro. 

Interpro

 IPR000836; PRibTrfase_dom.
 IPR005765; Ura_phspho_trans. 

Pfam

 PF00156; Pribosyltran 

SMART

  

PROSITE

  

PRINTS