CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037363
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Dystrophin 
Protein Synonyms/Alias
  
Gene Name
 DMD 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1592ATDMELTKRSAVEGMubiquitination[1]
1611DSEVAWGKATQKEIEubiquitination[1]
1640ALKTVLGKKETLVEDubiquitination[2, 3]
1641LKTVLGKKETLVEDKubiquitination[3]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; Calcium; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3681 AA 
Protein Sequence
MSEVSSDERE DVQKKTFTKW VNAQFSKFGK QHIENLFSDL QDGRRLLDLL EGLTGQKLPK 60
EKGSTRVHAL NNVNKALRVL QNNNVDLVNI GSTDIVDGNH KLTLGLIWNI ILHWQVKNVM 120
KNIMAGLQQT NSEKILLSWV RQSTRNYPQV NVINFTTSWS DGLALNALIH SHRPDLFDWN 180
SVVCQQSATQ RLEHAFNIAR YQLGIEKLLD PEDVDTTYPD KKSILMYITS LFQVLPQQVS 240
IEAIQEVEML PRPPKVTKEE HFQLHHQMHY SQQITVSLAQ GYERTSSPKP RFKSYAYTQA 300
AYVTTSDPTR SPFPSQHLEA PEDKSFGSSL MESEVNLDRY QTALEEVLSW LLSAEDTLQA 360
QGEISNDVEV VKDQFHTHEG YMMDLTAHQG RVGNILQLGS KLIGTGKLSE DEETEVQEQM 420
NLLNSRWECL RVASMEKQSN LHRVLMDLQN QKLKELNDWL TKTEERTRKM EEEPLGPDLE 480
DLKRQVQQHK VLQEDLEQEQ VRVNSLTHMV VVVDESSGDH ATAALEEQLK VLGDRWANIC 540
RWTEDRWVLL QDILLKWQRL TEEQCLFSAW LSEKEDAVNK IHTTGFKDQN EMLSSLQKLA 600
VLKADLEKKK QSMGKLYSLK QDLLSTLKNK SVTQKTEAWL DNFARCWDNL VQKLEKSTAQ 660
ISQAVTTTQP SLTQTTVMET VTTVTTREQI LVKHAQEELP PPPPQKKRQI TVDSEIRKRL 720
DVDITELHSW ITRSEAVLQS PEFAIFRKEG NFSDLKEKVN AIEREKAEKF RKLQDASRSA 780
QALVEQMVNE GVNADSIKQA SEQLNSRWIE FCQLLSERLN WLEYQNNIIA FYNQLQQLEQ 840
MTTTAENWLK IQPTTPSEPT AIKSQLKICK DEVNRLSDLQ PQIERLKIQS IALKEKGQGP 900
MFLDADFVAF TNHFKQVFSD VQAREKELQT IFDTLPPMRY QETMSAIRTW VQQSETKLSI 960
PQLSVTDYEI MEQRLGELQA LQSSLQEQQS GLYYLSTTVK EMSKKAPSEI SRKYQSEFEE 1020
IEGRWKKLSS QLVEHCQKLE EQMNKLRKIQ NHIQTLKKWM AEVDVFLKEE WPALGDSEIL 1080
KKQLKQCRLL VSDIQTIQPS LNSVNEGGQK IKNEAEPEFA SRLETELKEL NTQWDHMCQQ 1140
VYARKEALKG GLEKTVSLQK DLSEMHEWMT QAEEEYLERD FEYKTPDELQ KAVEEMKRAK 1200
EEAQQKEAKV KLLTESVNSV IAQAPPVAQE ALKKELETLT TNYQWLCTRL NGKCKTLEEV 1260
WACWHELLSY LEKANKWLNE VEFKLKTTEN IPGGAEEISE VLDSLENLMR HSEDNPNQIR 1320
ILAQTLTDGG VMDELINEEL ETFNSRWREL HEEAVRRQKL LEQSIQSAQE TEKSLHLIQE 1380
SLTFIDKQLA AYIADKVDAA QMPQEAQKIQ SDLTSHEISL EEMKKHNQGK EAAQRVLSQI 1440
DVAQKKLQDV SMKFRLFQKP ANFEQRLQES KMILDEVKMH LPALETKSVE QEVVQSQLNH 1500
CVNLYKSLSE VKSEVEMVIK TGRQIVQKKQ TENPKELDER VTALKLHYNE LGAKVTERKQ 1560
QLEKCLKLSR KMRKEMNVLT EWLAATDMEL TKRSAVEGMP SNLDSEVAWG KATQKEIEKQ 1620
KVHLKSITEV GEALKTVLGK KETLVEDKLS LLNSNWIAVT SRAEEWLNLL LEYQKHMETF 1680
DQNVDHITKW IIQADTLLDE SEKKKPQQKE DVLKRLKAEL NDIRPKVDST RDQAANLMAN 1740
RGDHCRKLVE PQISELNHRF AAISHRIKTG KASIPLKELE QFNSDIQKLL EPLEAEIQQG 1800
VNLKEEDFNK DMNEDNEGTV KELLQRGDNL QQRITDERKR EEIKIKQQLL QTKHNALKDL 1860
RSQRRKKALE ISHQWYQYKR QADDLLKCLD DIEKKLASLP EPRDERKIKE IDRELQKKKE 1920
ELNAVRRQAE GLSEDGAAMA VEPTQIQLSK RWREIESKFA QFRRLNFAQI HTVREETMMV 1980
MTEDMPLEIS YVPSTYLTEI THVSQALLEV EQLLNAPDLC AKDFEDLFKQ EESLKNIKDS 2040
LQQSSGRIDI IHSKKTAALQ SATPVERVKL QEALSQLDFQ WEKVNKMYKD RQGRFDRSVE 2100
KWRRFHYDIK IFNQWLTEAE QFLRKTQIPE NWEHAKYKWY LKELQDGIGQ RQTVVRTLNA 2160
TGEEIIQQSS KTDASILQEK LGSLNLRWQE VCKQLSDRKK RLEEQKNILS EFQRDLNEFV 2220
LWLEEADNIA SIPLEPGKEQ QLKEKLEQVK LLVEELPLRQ GILKQLNETG GPVLVSAPIS 2280
PEEQDKLENK LKQTNLQWIK VSRALPEKQG EIEAQIKDLG QLEKKLEDLE EQLNHLLLWL 2340
SPIRNQLEIY NQPNQEGPFD VKETEIAVQA KQPDVEEILS KGQHLYKEKP ATQPVKRKLE 2400
DLSSEWKAVN RLLQELRAKQ PDLAPGLTTI GASPTQTVTL VTQPVVTKET AISKLEMPSS 2460
LMLEVPALAD FNRAWTELTD WLSLLDQVIK SQRVMVGDLE DINEMIIKQK ATMQDLEQRR 2520
PQLEELITAA QNLKNKTSNQ EARTIITDRI ERIQNQWDEV QEHLQNRRQQ LNEMLKDSTQ 2580
WLEAKEEAEQ VLGQARAKLE SWKEGPYTVD AIQKKITETK QLAKDLRQWQ TNVDVANDLA 2640
LKLLRDYSAD DTRKVHMITE NINASWRSIH KRVSEREAAL EETHRLLQQF PLDLEKFLAW 2700
LTEAETTANV LQDATRKERL LEDSKGVKEL MKQWQDLQGE IEAHTDVYHN LDENSQKILR 2760
SLEGSDDAVL LQRRLDNMNF KWSELRKKSL NIRSHLEASS DQWKRLHLSL QELLVWLQLK 2820
DDELSRQAPI GGDFPAVQKQ NDVHRAFKRE LKTKEPVIMS TLETVRIFLT EQPLEGLEKL 2880
YQEPRELPPE ERAQNVTRLL RKQAEEVNTE WEKLNLHSAD WQRKIDETLE RLRELQEATD 2940
ELDLKLRQAE VIKGSWQPVG DLLIDSLQDH LEKVKALRGE IAPLKENVSH VNDLARQLTT 3000
LGIQLSPYNL STLEDLNTRW KLLQVAVEDR VRQLHEAHRD FGPASQHFLS TSVQGPWERA 3060
ISPNKVPYYI NHETQTTCWD HPKMTELYQS LADLNNVRFS AYRTAMKLRR LQKALCLDLL 3120
SLSAACDALD QHNLKQNDQP MDILQIINCL TTIYDRLEQE HNNLVNVPLC VDMCLNWLLN 3180
VYDTGRTGRI RVLSFKTGII SLCKAHLEDK YRYLFKQVAS STGFCDQRRL GLLLHDSIQI 3240
PRQLGEVASF GGSNIEPSVR SCFQFANNKP EIEAALFLDW MRLEPQSMVW LPVLHRVAAA 3300
ETAKHQAKCN ICKECPIIGF RYRSLKHFNY DICQSCFFSG RVAKGHKMHY PMVEYCTPTT 3360
SGEDVRDFAK VLKNKFRTKR YFAKHPRMGY LPVQTVLEGD NMETPVTLIN FWPVDSAPAS 3420
SPQLSHDDTH SRIEHYASRL AEMENSNGSY LNDSISPNES IDDEHLLIQH YCQSLNQDSP 3480
LSQPRSPAQI LISLESEERG ELERILADLE EENRNLQAEY DRLKQQHEHK GLSPLPSPPE 3540
MMPTSPQSPR DAELIAEAKL LRQHKGRLEA RMQILEDHNK QLESQLHRLR QLLEQPQAEA 3600
KVNGTTVSSP STSLQRSDSS QPMLLRVVGS QTSDSMGEED LLSPPQDTST GLEEVMEQLN 3660
NSFPSSRGRN TPGKPMREDT M 3681 
Gene Ontology
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR001589; Actinin_actin-bd_CS.
 IPR001715; CH-domain.
 IPR016344; Dystrophin/utrophin.
 IPR011992; EF-hand-like_dom.
 IPR015153; EF-hand_dom_typ1.
 IPR015154; EF-hand_dom_typ2.
 IPR018159; Spectrin/alpha-actinin.
 IPR002017; Spectrin_repeat.
 IPR001202; WW_dom.
 IPR000433; Znf_ZZ. 
Pfam
 PF00307; CH
 PF09068; efhand_1
 PF09069; efhand_2
 PF00435; Spectrin
 PF00397; WW
 PF00569; ZZ 
SMART
 SM00033; CH
 SM00150; SPEC
 SM00456; WW
 SM00291; ZnF_ZZ 
PROSITE
 PS00019; ACTININ_1
 PS00020; ACTININ_2
 PS50021; CH
 PS01159; WW_DOMAIN_1
 PS50020; WW_DOMAIN_2
 PS01357; ZF_ZZ_1
 PS50135; ZF_ZZ_2 
PRINTS