CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013913
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 U3 small nucleolar RNA-associated protein 18 homolog 
Protein Synonyms/Alias
 WD repeat-containing protein 50 
Gene Name
 Utp18 
Gene Synonyms/Alias
 Wdr50 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
325VYDMLAGKLIPVHQVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity). 
Sequence Annotation
 REPEAT 245 284 WD 1.
 REPEAT 289 329 WD 2.
 REPEAT 376 415 WD 3.
 REPEAT 417 458 WD 4.
 REPEAT 467 508 WD 5.
 REPEAT 515 551 WD 6.
 MOD_RES 114 114 Phosphoserine.
 MOD_RES 115 115 Phosphoserine.
 MOD_RES 118 118 Phosphoserine.
 MOD_RES 200 200 Phosphothreonine (By similarity).
 MOD_RES 201 201 Phosphoserine.
 MOD_RES 202 202 Phosphoserine.
 MOD_RES 206 206 Phosphoserine.  
Keyword
 Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; rRNA processing; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 552 AA 
Protein Sequence
MPPERKSRTR RDRRAGATPG RKARPGSGST PAKAARSSQR TQPAEPRAAP SAGSAAAAAE 60
EEESRLRQRN RLTLEDDKPA AERCLEQLVF GDVEDDEDAL LQRLRSSRGQ LHGSSDESEV 120
ENEAKDIFSQ KKKQPVWVDE DDEDEEIVDM SNNRFRKDIM KNASESKLSK DKLQKRLKEE 180
FQHAMGGVPD WAEAGSKRRT SSDDESEEDE DDLLQRTGNF ISTSTSLPRG ILKMKNCRPA 240
NAERPTTARI SSVQFHPGAQ VVMVSGVDNA ISLFQVDGKT NPKIQSIYLE KFPIFKACFS 300
ANGEEVLATS MHSKVLYVYD MLAGKLIPVH QVRGLKEKTV KQFEVSPDGS FLLISGIAGF 360
SHLLSMKTKE LIGSMKINGR IAASTFSSDS KRIYTYSENG EVYVWDVNSR KCMNRFLDEG 420
SLCGLSIAAS KNGQYVACGS KSGVVNIYNQ DSCLQQTNPK PIKAIMNLVT GVTSLAFNPT 480
TEILAVASRK MKEAVRLVHL PSCTVFSNFP VFKKSTLSRV QTMDFSPRGG YFALGNEKGR 540
ALMYRLHHYS DF 552 
Gene Ontology
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. 
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
  
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS