CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038185
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Dystonin 
Protein Synonyms/Alias
  
Gene Name
 Dst 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
3655DRALIEQKLNEVKMKacetylation[1]
5739KLDKVLKKYDAVCQIacetylation[2]
6561EIANDPDKIKAQLVQubiquitination[3]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; Calcium; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 7393 AA 
Protein Sequence
MAGYLSPAAY MYVEEQEYLQ AYEDVLERYK DERDKVQKKT FTKWINQHLM KVRKHVNDLY 60
EDLRDGHNLI SLLEVLSGDT LPREKGRMRF HRLQNVQIAL DYLKRRQVKL VNIRNDDITD 120
GNPKLTLGLI WTIILHFQIS DIHVTGESED MSAKERLLLW TQQATEGYAG VRCENFTTCW 180
RDGKLFNAII HKYRPDLIDM NTVAVQSNLA NLEHAFYVAE KIGVIRLLDP EDVDVSSPDE 240
KSVITYVSSL YDAFPKVPEG GEGIGANDVE VKWIEYQNMV NYLIQWIRHH VVTMSERTFP 300
NNPLELKALY NQYLQFKEKE IPPKEMEKSK IKRLYKLLEI WIEFGRIKLL QGYHPNDIEK 360
EWGKLIIAML EREKALRPEV ERLDMLQQIA TRVQRDSVSC EDKLILARNA LQSDSKRLES 420
GVQFQNEAEI AGYILECENL LRQHVIDVQI LIDGKYYQAD QLVQRVAKLR DEIMALRNEC 480
SSVYSKGRML TTEQTKLMIS GITQSLNSGF AQTLHPSLNS GLTQSLTPSL TSSSVTSGLS 540
SGMTSRLTPS VTPVYAPGFP SVVAPNFSLG VEPNSLQTLK LMQIRKPLLK SSLLDQNLTE 600
EEVNMKFVQD LLNWVDEMQV QLDRTEWGSD LPSVESHLEN HKNVHRAIEE FESSLKEAKI 660
SEIQMTAPLK LSYTDKLHRL ESQYAKLLNT SRNQERHLDT LHNFVTRATN ELIWLNEKEE 720
SEVAYDWSER NSSVARKKSY HAELMRELEQ KEESIKAVQE IAEQLLLENH PARLTIEAYR 780
AAMQTQWSWI LQLCQCVEQH IQENSAYFEF FNDAKEATDY LRNLKDAIQR KYSCDRSSSI 840
HKLEDLVQES MEKEELLQYR SVVAGLMGRA KTVVQLKPRN PDNPLKTSIP IKAICDYRQI 900
EITIYKDDEC VLANNSHRAK WKVISPTGNE AMVPSVCFTV PPPNKEAVDF ANRIEQQYQS 960
VLTLWHESHI NMKSVVSWHY LVNEIDRIRA SNVASIKTML PGEHQQVLSN LQSRLEDFLE 1020
DSQESQIFSG SDISQLEKEV SVCRKYYQEL LKSAEREEQE ESVYNLYISE VRNIRLRLES 1080
CEDRLIRQIR TPLERDDLHE SMLRITEQEK LKKELDRLKD DLGTITNKCE EFFSQAADSP 1140
SVPALRSELS VVIQSLSQIY SMSSTYIEKL KTVNLVLKNT QAAEALVKLY ETKLCEEEAV 1200
IADKNNIENL MSTLKQWRSE VDEKREVFHA LEDELQKAKA ISDEMFKTHK ERDLDFDWHK 1260
EKADQLVERW QSVHVQIDNR LRDLEGIGKS LKHYRDSYHP LDDWIQHIET TQRKIQENQP 1320
ENSKALALQL NQQKMLVSEI EVKQSKMDEC QKYSEQYSAA VKDYELQTMT YRAMVESQQK 1380
SPVKRRRIQS SADLVIQEFM DLRTRYTALV TLMTQYIKFA GDSLKRLEEE EKSLDEEKKQ 1440
HIEKAKELQK WVSNISKTLG DGEKAGKPLF SKQQMSSKEI STKKEQFSEA LQTTQIFLAK 1500
HGDKLTEEER SDLEKQVKTL QEGYNLLFSE SLKQQELQPS GESKVPEKPD KVIAGTINQT 1560
TGEVLSVFQA VLRGLIDYET GIRLLEAQLV ITGLISPELR KCFDLRDAES HGLIDEQVLR 1620
QLKELNRAKQ LISTASPTSI PVLDSLAQGM VSESMAIRVL EILLSAGPLL VPATGEHLTL 1680
QQAFQQNLIS SALFSKVLER QDTCKDLIDP CTSEKVSLTD MVQRSILQEN TRMWLLPVRP 1740
QEAGRITLKC GRSVSILRAA HEGLIDRETM FRLLGAQLLS GGLIDCNSGQ KMTVEEAVAE 1800
GVIDRDTASS ILTYQVQTGG IVHSNPAKRL TVDEAVQCEL ITSSSALLVL EAQRGYVGLI 1860
WPHSGEIFPT SSSLQQELIT NELASKILNG RQKIAALYIP ESSQVIGLDA AKQLGIIDNN 1920
TASVLKSVTL PDKMPDLGDL EDCKNAKRWL SFCKLQPSTV HDYRQEEGGS DGEEPVTAQS 1980
SEQTKKLFLS YLMVNSYMDA HTGQRLLLYD GDLDEAVGML LESCGTELGA DTSTRESLSV 2040
LTIPDAFPDC ALSEEKHECS AAAAGPDKCH YSHPGHKESL ENAKWDMNEA FCKMGNNDSN 2100
GELPRPENLA DTTVVQKGSE SPSRVRVPKP TSSSTQPEGS VLRPESGSIL KGCKSQSEPV 2160
TKKYPDGANH SHFLTSETSR PCDSNEREDE ENIQKGPSVF DYSPRLSALL SHDELRQSQG 2220
RFSDTSTPQN TGYLCEASTL SPSDQRVLAD QSTREKFQDQ FLGIAAISVS LQGAPCGQKP 2280
VDTECSSSQV HYHSEESMSD ASAESGATRQ TDESEKTGSK VEDNSCTMVP GGGSRNDNTS 2340
DCGPLSHKGA IDAGDYETSL LAGQQSDTAT DSDSDDYFYD TPLFEDEDHD SLILQGDDRD 2400
CLQPEDYDTS LQEENDRTPP PDDIFYDVMK EKENPEFPHG GMDESLGVEN KVCCPQGFPV 2460
GIEKPELYLA GEKEFNSGGS EQLVESVSES ENPPGLWDSE SDSLTEGEII GRKERLGASL 2520
TPDGHWRGDR EECDTSRESQ SDTDGVGSIQ SSESYRPYMS DGSDLDEEDN GGRSSEDSGD 2580
GRGGQGVADE GGEPQYQADP TQLYTAIRKE HGGETQNVSD MIPLDKTHSY SPLETQHGAG 2640
VFQPESAGRG GWDTERSSHP ELTTEADEED EASLSTHMAT KGVSLSNAEG TASEEIRLVQ 2700
GPDSTGILKA EDLENVSPEI SPSSDNIVRS EAELGGGASE DGHLSFTGSD RDQQGPGRGL 2760
VKGRDGQSDK LVDETSIREM GFQKEGVLMS SPEEGGEEER DLEPFPNGSA TESLNMGKSQ 2820
VPPLLTHTEE LSHRGAPHTT TMTTTMTLEG EAKNVQTGLT ESPVLLETLA EIFDTPASKV 2880
TRADLTSAVT ASEMKSQVKE DSLTGGPEKE TGPCTSLGHC DKCIHVDMLE PNEHTPSCAL 2940
VAPPTVKDNL CSVNNAGEKS VRPQEDWPPA AEVRLSDACV EESISEGKAG ILQFTPENSD 3000
STLSRLPHQS VAGWGKSADS VQARLPVSGV RHTSADTLDV GCPQLESSRE KASAEEEPHR 3060
ERALSLKPQE REHHMLGFVE DGRSILKSSL DKVHMNLQEV GDPSAGTGTK ISIQNLIRRA 3120
ILSELPNEVS NVPSHGISPI SNSSEVRAES GGDPFCITSF LHLLKQNQPP QETPGISELA 3180
KVLTQMDCDP EQRGLGSELL PPQLKNAFYK LLFDGYATEK DQAEALGQTS CAVPKMAEEK 3240
PHVCSDLRNK EGHHCPLNPQ AVGEAEVEPF SVHIAALPGG EKLGELCSEP PEHSESTSGS 3300
KERSSDSSSK EKCSNGLQQC LQHTEKMHEY LVLLQDMKPP LDNQASVESS LEALKSQLKQ 3360
LEAFELGLAP IAVFLRKDLK LAEEFLKSFP SDLPRRHHEE LSKSHQRLQN AFSSLSSVSS 3420
ERMKLIKLAI NSEMSKLAVR HEDFLHKLTS YSDWVSEKSR SVKAIQTVNV QDTELVKNSV 3480
KFLKNVLADL SHTKMQLETT AFDVQSFISD YAQDLSPSQS RQLLRLLNTT QKGFLDLQEL 3540
VTTEADRLEA LLQLEQELGH QKVVAERQQE YREKLQGLCD LLTQTENRLI SNQEAFVIGD 3600
GTVELQKYQS KQEELQRDMQ GSTQAMEEIV RNTELFLKES GDELSQADRA LIEQKLNEVK 3660
MKCAQLNLKA EQSRKELDKA VTTALKEETE KVAAVRQLEE SKTKIENLLN WLSNVEEDSE 3720
GVWTKHTQPM EQNGTYLHEG DSKLGAGEED EVNGNLLETD AEGHSEATKG NLNQQYEKVK 3780
AQHGKIMAQH QAVLLATQSA QVLLEKQGHY LSPEEKEKLQ KNTQELKVHY EKVLAECEKK 3840
VKLTHSLQEE LEKFDTDYSE FEHWLQQSEQ ELANLEAGAD DLSGLMDKLT RQKSFSEDVI 3900
SHKGDLRYIT ISGNRVIDAA KSCSKRDSDR IGKDSVETSA THREVQTKLD QVTDRFRSLY 3960
SKCSVLGNNL KDLVDQYQQY EDASCGLLSG LQACEAKASK HLREPIALDP KNLQRQLEET 4020
KALQGQISSQ QVAVEKLKKT AEVLLDAKGS LLPAKNDIQK TLDDIVGRYD DLSKCVNERN 4080
EKLQITLTRS LSVQDALDEM LDWMGSVESS LVKPGQVPLN STALQDLISK DTMLEQDITG 4140
RQSSINAMNE KVKTFIETTD PSTASSLQAK MKDLSARFSE ASQKHKEKLA KMVELKAKVE 4200
QFEKLSDKLQ TFLETQSQAL TEVAMPGKDV PELSQHMQES TAKFLEHRKD LEALHSLLKE 4260
ISSHGLPGDK ALVFEKTNNL SRKFKEMEDT IQEKKDALSS CQEQLSAFQT LAQSLKTWIK 4320
ETTKQVPVVK PSLGTEDLRK SLEETKKLQE KWNLKAPEIH KANNSGVSLC NLLSALISPA 4380
KAIAAAKSGG VILNGEGTDT NTQDFLANKG LTSIKKDMTD ISHSYEDLGL LLKDKIVELN 4440
TKLSKLQKAQ EESSAMMQWL EKMNKTASRW RQTPTPADTE SVKLQVEQNK SFEAELKQNV 4500
NKVQELKDKL SELLEENPEA PEAQSWKQAL AEMDTKWQEL NQLTMDRQQK LEESSNNLTQ 4560
FQTTEAQLKQ WLMEKELMVS VLGPLSIDPN MLNTQKQQVQ ILLQEFDTRK PQYEQLTAAG 4620
QGILSRPGED PSLHGIVNEQ LEAVTQKWDN LTGQLRDRCD WIDQAIVKST QYQSLLRSLS 4680
GTLTELDDKL SSGLTSGALP DAVNQQLEAA QRLKQEIEQQ APKIKEAQEV CEDLSALVKE 4740
EYLKAELSRQ LEGILKSFKD IEQKTENHVQ HLQSACASSH QFQQMSKDFQ AWLDAKKEEQ 4800
RDSPPISAKL DVLESLLNSQ KDFGKTFTEQ SNIYEKTISE GENLLLKTQG AEKAALQLQL 4860
NTMKTDWDRF RKQVKEREEK LKDSLEKALK YREQVETLRP WIDRCQHSLD GVTFSLDPTE 4920
SESSIAELKS LQKEMDHHFG MLELLNNTAN SLLSVCEVDK EAVTEENQSL MEKVNRVTEQ 4980
LQSKTVSLEN MAQKFKEFQE VSRDTQRQLQ DTKEQLEVHH SLGPQAYSNK HLSVLQAQQK 5040
SLQTLKQQVD EAKRLAQDLV VEAADSKGTS DVLLQAETLA EEHSELSQQV DEKCSFLETK 5100
LQGLGHFQNT IREMFSQFTE CDDELDGMAP VGRDAETLRK QKACMQTFLK KLEALMASND 5160
SANRTCKMML ATEETSPDLI GVKRDLEALS KQCNKLLDRA KTREEQVDGA TEKLEEFHRK 5220
LEEFSTLLQK AEEHEESQGP VGTETETINQ QLDVFKVFQK EEIEPLQVKQ QDVNWLGQGL 5280
IQSAAANTCT QGLEHDLDSV NSRWKTLNKK VAQRTSQLQE ALLHCGRFQD ALESLLSWMA 5340
DTEELVANQK PPSAEFKVVK AQIQEQKLLQ RLLEDRKSTV EVIKREGEKI AASAEPADRV 5400
KLTRQLSLLD SRWEALLSRA EARNRQLEGI SVVAQEFHET LEPLNEWLTA VEKKLANSEP 5460
IGTQAPKLEE QISQHKALQE DILLRKQSVD QALLNGLELL KQTTGDEVLI IQDKLEAIKA 5520
RYKDITKLSA DVAKTLEHAL QLAGQLQSMH KELCNWLDKV EVELLSYETQ GLKGEAASQV 5580
QERQKELKNE VRSNKALVDS LNEVSSALLE LVPWRAREGL EKTIAEDNER YRLVSDTITQ 5640
KVEEIDAAIL RSQQFEQAAD AELSWITETQ KKLMSLGDIR LEQDQTSAQL QVQKAFTMDI 5700
LRHKDIIDEL VTSGHKIMTT SSEEEKQSMK KKLDKVLKKY DAVCQINSER HLQLERAQSL 5760
VSQFWETYEE LWPWLTETQR IISQLPAPAL EYETLRRQQE EHRQLRELIA EHKPHIDKMN 5820
KTGPQLLELS PKEGIYIQEK YVAADTLYSQ IKEDVKKRAV VLDEAISQST QFHDKIDQIL 5880
ESLERIAERL RQPPSISAEV EKIKEQIGEN KSVSVDMEKL QPLYETLRQR GEEMIARSEG 5940
TEKDVSARAV QDKLDQMVFI WGSIHTLVEE REAKLLDVME LAEKFWCDHM SLVVTIKDTQ 6000
DFIRDLEDPG IDPSVVKQQQ EAAEAIREEI DGLQEELDMV ITLGSELIAA CGEPDKPIVK 6060
KSIDELNSAW DSLNKAWKDR VDRLEEAMQA AVQYQDGLQG IFDWVDIAGN KLATMSPIGT 6120
DLETVKQQIE ELKQFKSEAY QQQIEMERLN HQAELLLKKV TEEADKHTVQ DPLMELKLIW 6180
DSLDERIVSR QHKLEGALLA LGQFQHALDE LLAWLTHTKG LLSEQKPVGG DPKAIEIELA 6240
KHHVLQNDVL AHQSTVEAVN KAGNDLIESS EGEEASNLQY KLRILNQRWQ DILEKTDQRK 6300
QQLDSALRQA KGFHGEIEDL QQWLTDTERH LLASKPLGGL PETAKEQLNA HMEVCTAFAI 6360
KEETYKSLML RGQQMLARCP RSAETNIDQD ITNLKEKWES VKSKLNEKKT KLEEALHLAM 6420
NFHNSLQDFI NWLTQAEQTL NVASRPSLIL DTILFQIDEH KVFANEVNSH REQIIELDKT 6480
GTHLKYFSQK QDVVLIKNLL ISVQSRWEKV VQRLVERGRS LDEARKRAKQ FHEAWSKLME 6540
WLEESEKSLD SELEIANDPD KIKAQLVQHK EFQKSLGGKH SVYDTTNRTG RSLKEKTSLA 6600
DDNLKLDNML SELRDKWDTI CGKSVERQNK LEEALLFSGQ FTDALQALID WLYRVEPQLA 6660
EDQPVHGDID LVMNLIDNHK VFQKELGKRT SSVQALKRSA RELIEGSRDD SSWVRVQMQE 6720
LSTRWETVCA LSISKQTRLE SALQQAEEFH SVVHTLLEWL AEAEQTLRFH GALPDDEDAL 6780
RTLIEQHKEF MKRLEEKRAE LSKATGMGDA LLAVCHPDSI TTIKHWITII QARFEEVLAW 6840
AKQHQQRLAG ALAGLIAKQE LLETLLAWLQ WAETTLTEKD KEVIPQEIEE VKTLIAEHQT 6900
FMEEMTRKQP DVDKVTKTYK RRATDPPSLQ SHIPVLDKGR AGRKRFPASG FYPSGSQTQI 6960
ETKNPRVNLL VSKWQQVWLL ALERRRKLND ALDRLEELRE FANFDFDIWR KKYMRWMNHK 7020
KSRVMDFFRR IDKDQDGKIT RQEFIDGILS SKFPTSRLEM SAVADIFDRD GDGYIDYYEF 7080
VAALHPNKDA YKPITDADKI EDEVTRQVAK CKCAKRFQVE QIGDNKYRFF LGNQFGDSQQ 7140
LRLVRILRST VMVRVGGGWM ALDEFLVKND PCRVHHHGSK MLRSESNSSI TATQPTLAKG 7200
RTNMELREKF ILADGASQGM AAFRPRGRRS RPSSRGASPN RSTSASSHAC QAASPPVPAA 7260
ASTPKGTPIQ GSKLRLPGYL SGKGFHSGED SALITTAAAR VRTQFAESRK TPSRPGSRAG 7320
SKAGSRASSR RGSDASDFDI SEIQSVCSDV ETVPQTHRPV PRAGSRPSTA KPSKIPTPQR 7380
RSPASKLDKS SKR 7393 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IDA:MGI.
 GO:0031252; C:cell leading edge; IEA:Compara.
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; ISO:MGI.
 GO:0030056; C:hemidesmosome; IDA:MGI.
 GO:0015630; C:microtubule cytoskeleton; IDA:MGI.
 GO:0035371; C:microtubule plus end; IEA:Compara.
 GO:0060053; C:neurofilament cytoskeleton; IDA:MGI.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0008017; F:microtubule binding; IDA:MGI.
 GO:0007409; P:axonogenesis; IMP:MGI.
 GO:0007050; P:cell cycle arrest; IEA:InterPro.
 GO:0048870; P:cell motility; IEA:Compara.
 GO:0031122; P:cytoplasmic microtubule organization; IMP:MGI.
 GO:0031581; P:hemidesmosome assembly; IEA:Compara.
 GO:0030011; P:maintenance of cell polarity; IEA:Compara.
 GO:0031110; P:regulation of microtubule polymerization or depolymerization; IMP:MGI.
 GO:0009611; P:response to wounding; IEA:Compara.
 GO:0008090; P:retrograde axon cargo transport; IMP:MGI. 
Interpro
 IPR001589; Actinin_actin-bd_CS.
 IPR001715; CH-domain.
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR003108; GAS2_dom.
 IPR001101; Plectin_repeat.
 IPR018159; Spectrin/alpha-actinin.
 IPR002017; Spectrin_repeat. 
Pfam
 PF00307; CH
 PF13499; EF_hand_5
 PF02187; GAS2
 PF00681; Plectin
 PF00435; Spectrin 
SMART
 SM00033; CH
 SM00054; EFh
 SM00243; GAS2
 SM00250; PLEC
 SM00150; SPEC 
PROSITE
 PS00019; ACTININ_1
 PS00020; ACTININ_2
 PS50021; CH
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS51460; GAR 
PRINTS