| Tag | Content |
|---|
| CPLM ID | CPLM-004288 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Helicase IV |
Protein Synonyms/Alias | 75 kDa helicase |
Gene Name | helD |
Gene Synonyms/Alias | b0962; JW0945 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 158 | NCREAWRKCQAWLKD | acetylation | [1] | | 164 | RKCQAWLKDIESARL | acetylation | [1] | | 295 | KKVPIVSKLENDTAA | acetylation | [1] | | 579 | MRPASLEKAATRWPK | acetylation | [1] | | 586 | KAATRWPKLQIDFMT | acetylation | [1] | | 663 | RVWALFNKENPSPFV | acetylation | [1] | | 674 | SPFVEILKNLDVPVA | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Helicase IV catalyzes the unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand in a reaction that is dependent upon the hydrolysis of ATP. |
Sequence Annotation | DOMAIN 195 505 UvrD-like helicase ATP-binding.
NP_BIND 216 223 ATP (Probable).
BINDING 503 503 ATP (By similarity). |
Keyword | ATP-binding; Complete proteome; Direct protein sequencing; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 684 AA |
Protein Sequence | MELKATTLGK RLAQHPYDRA VILNAGIKVS GDRHEYLIPF NQLLAIHCKR GLVWGELEFV 60
LPDEKVVRLH GTEWGETQRF YHHLDAHWRR WSGEMSEIAS GVLRQQLDLI ATRTGENKWL 120
TREQTSGVQQ QIRQALSALP LPVNRLEEFD NCREAWRKCQ AWLKDIESAR LQHNQAYTEA 180
MLTEYADFFR QVESSPLNPA QARAVVNGEH SLLVLAGAGS GKTSVLVARA GWLLARGEAS 240
PEQILLLAFG RKAAEEMDER IRERLHTEDI TARTFHALAL HIIQQGSKKV PIVSKLENDT 300
AARHELFIAE WRKQCSEKKA QAKGWRQWLT EEMQWSVPEG NFWDDEKLQR RLASRLDRWV 360
SLMRMHGGAQ AEMIASAPEE IRDLFSKRIK LMAPLLKAWK GALKAENAVD FSGLIHQAIV 420
ILEKGRFISP WKHILVDEFQ DISPQRAALL AALRKQNSQT TLFAVGDDWQ AIYRFSGAQM 480
SLTTAFHENF GEGERCDLDT TYRFNSRIGE VANRFIQQNP GQLKKPLNSL TNGDKKAVTL 540
LDESQLDALL DKLSGYAKPE ERILILARYH HMRPASLEKA ATRWPKLQID FMTIHASKGQ 600
QADYVIIVGL QEGSDGFPAA ARESIMEEAL LPPVEDFPDA EERRLMYVAL TRARHRVWAL 660
FNKENPSPFV EILKNLDVPV ARKP 684 |
Gene Ontology | GO:0033202; C:DNA helicase complex; IDA:EcoCyc. GO:0016020; C:membrane; IEA:InterPro. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0043140; F:ATP-dependent 3'-5' DNA helicase activity; IDA:EcoCyc. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro. GO:0006310; P:DNA recombination; IMP:EcoCyc. GO:0000160; P:phosphorelay signal transduction system; IEA:GOC. GO:0023014; P:signal transduction by phosphorylation; IEA:GOC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |