CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023197
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein-arginine deiminase type-3 
Protein Synonyms/Alias
 Peptidylarginine deiminase III; Protein-arginine deiminase type III 
Gene Name
 PADI3 
Gene Synonyms/Alias
 PDI3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
209HTSSYDAKRAQVFHIubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Catalyzes the deimination of arginine residues of proteins. 
Sequence Annotation
  
Keyword
 Calcium; Complete proteome; Cytoplasm; Hydrolase; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 664 AA 
Protein Sequence
MSLQRIVRVS LEHPTSAVCV AGVETLVDIY GSVPEGTEMF EVYGTPGVDI YISPNMERGR 60
ERADTRRWRF DATLEIIVVM NSPSNDLNDS HVQISYHSSH EPLPLAYAVL YLTCVDISLD 120
CDLNCEGRQD RNFVDKRQWV WGPSGYGGIL LVNCDRDDPS CDVQDNCDQH VHCLQDLEDM 180
SVMVLRTQGP AALFDDHKLV LHTSSYDAKR AQVFHICGPE DVCEAYRHVL GQDKVSYEVP 240
RLHGDEERFF VEGLSFPDAG FTGLISFHVT LLDDSNEDFS ASPIFTDTVV FRVAPWIMTP 300
STLPPLEVYV CRVRNNTCFV DAVAELARKA GCKLTICPQA ENRNDRWIQD EMELGYVQAP 360
HKTLPVVFDS PRNGELQDFP YKRILGPDFG YVTREPRDRS VSGLDSFGNL EVSPPVVANG 420
KEYPLGRILI GGNLPGSSGR RVTQVVRDFL HAQKVQPPVE LFVDWLAVGH VDEFLSFVPA 480
PDGKGFRMLL ASPGACFKLF QEKQKCGHGR ALLFQGVVDD EQVKTISINQ VLSNKDLINY 540
NKFVQSCIDW NREVLKRELG LAECDIIDIP QLFKTERKKA TAFFPDLVNM LVLGKHLGIP 600
KPFGPIINGC CCLEEKVRSL LEPLGLHCTF IDDFTPYHML HGEVHCGTNV CRKPFSFKWW 660
NMVP 664 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0004668; F:protein-arginine deiminase activity; TAS:ProtInc.
 GO:0018101; P:peptidyl-citrulline biosynthetic process from peptidyl-arginine; IEA:InterPro. 
Interpro
 IPR008972; Cupredoxin.
 IPR004303; PAD.
 IPR013530; PAD_C.
 IPR013732; PAD_N.
 IPR013733; Prot_Arg_deaminase_cen_dom.
 IPR016296; Protein-arginine_deiminase_sub. 
Pfam
 PF03068; PAD
 PF08527; PAD_M
 PF08526; PAD_N 
SMART
  
PROSITE
  
PRINTS